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<p>The functionalization of doped niobium (Nb) and nitrogen (N) titanium dioxide nanoparticles (Nb-NTO NPs), followed by bioactive extracts inherited by&#xa0;<i>Mucuna pruriens</i>&#xa0;beans methanolic extracts and ethanolic extracts of&#xa0;<i>Mentha arvensis</i>,&#xa0;offers fostering a synergistic enhancement of antibacterial and anti-inflammatory potential. This study evaluates the antibacterial and anti-inflammatory capabilities of those functionalized Nb-NTO NPs (F-Nb-NTO) compared to pure doped Nb-NTO NPs. These F-Nb-NTO underwent characterization through XRD, TEM, SEM, and EDS analysis. The antibacterial activities were evaluated by inactivating <i>Bacillus subtilis</i> and <i>Escherichia coli</i> based on agar plates showed a zone of inhibition (ZOI), with minimum inhibitory concentration (MIC) values recorded at 50&#xa0;μg/mL for different bacterial strains. <i>Escherichia coli</i> showed higher susceptibility, with a MIC value of 50&#xa0;μg/mL, while <i>Bacillus subtilis</i> was less susceptible. Subsequently, their anti-inflammatory demonstrated that F-Nb-NTO alleviated anti-inflammatory activity lipopolysaccharides (LPS)-induced inflammation in mouse RAW264.7 cell line. In vitro analysis showed that functionalized Nb-NTO significantly inhibited LPS-stimulated nitric oxide production compared to pure Nb-NTO NPs. The results demonstrated that F-Nb-NTO NPs exhibit significant antibacterial and anti-inflammatory properties compared to pure Nb-NTO NPs. In conclusion, this research highlights the potential of doped Nb-NTO NPs functionalized by <i>M. pruriens</i> and <i>M. arvensis</i> extracts for biomedical applications, particularly in antibacterial and anti-inflammatory treatments.</p>

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Evaluation of antimicrobial and anti-inflammatory activity of functionalized niobium nitrogen-doped titanium dioxide (Nb-NTO) nanoparticles

  • 期刊论文

  • 发表日期：

    2025年5月11日

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  • Muhammad Awais Farooqi,
  • Farzana Kausar,
  • Sehui Kim,
  • Sungmin Bae,
  • Lubna Anjum Minhas,
  • Hafiz Muhammad Umer Farooqi,
  • Chul Ung Kang

摘要

The functionalization of doped niobium (Nb) and nitrogen (N) titanium dioxide nanoparticles (Nb-NTO NPs), followed by bioactive extracts inherited by Mucuna pruriens beans methanolic extracts and ethanolic extracts of Mentha arvensis, offers fostering a synergistic enhancement of antibacterial and anti-inflammatory potential. This study evaluates the antibacterial and anti-inflammatory capabilities of those functionalized Nb-NTO NPs (F-Nb-NTO) compared to pure doped Nb-NTO NPs. These F-Nb-NTO underwent characterization through XRD, TEM, SEM, and EDS analysis. The antibacterial activities were evaluated by inactivating Bacillus subtilis and Escherichia coli based on agar plates showed a zone of inhibition (ZOI), with minimum inhibitory concentration (MIC) values recorded at 50 μg/mL for different bacterial strains. Escherichia coli showed higher susceptibility, with a MIC value of 50 μg/mL, while Bacillus subtilis was less susceptible. Subsequently, their anti-inflammatory demonstrated that F-Nb-NTO alleviated anti-inflammatory activity lipopolysaccharides (LPS)-induced inflammation in mouse RAW264.7 cell line. In vitro analysis showed that functionalized Nb-NTO significantly inhibited LPS-stimulated nitric oxide production compared to pure Nb-NTO NPs. The results demonstrated that F-Nb-NTO NPs exhibit significant antibacterial and anti-inflammatory properties compared to pure Nb-NTO NPs. In conclusion, this research highlights the potential of doped Nb-NTO NPs functionalized by M. pruriens and M. arvensis extracts for biomedical applications, particularly in antibacterial and anti-inflammatory treatments.