<p>Conventional flotation techniques often encounter challenges when processing oxidized ores, highlighting the necessity for developing advanced or improved flotation methods. This study investigated the effects of ZnO and Al₂O₃ nanocollectors on the flotation of smithsonite, optimizing the process parameters using a comprehensive definitive screening design. Initially, ZnO and Al₂O₃ nanoparticles were synthesized and subsequently modified with sodium dodecyl sulfate. Successful synthesis and surface modification of these nanocollectors were confirmed through transmission electron microscopy, X-ray diffraction, and Fourier-transform infrared spectroscopy. Flotation results demonstrated that ZnO and Al₂O₃ nanocollectors significantly enhanced mineral recovery compared to conventional collectors due to their increased surface area and improved interactions with smithsonite particles. Optimal flotation conditions were determined to be: pH 6.0, pulp density 7.0%, airflow rate 1.0&#xa0;L/min, oleic acid dosage 360&#xa0;g/t, ZnO nanocollector dosage 180&#xa0;g/t, Al₂O₃ nanocollector dosage 250&#xa0;g/t, and A65 frother dosage 17&#xa0;g/t, yielding a peak recovery of 91.1%.</p> Graphical abstract <p></p>