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Background <p>Bariatric surgery is effective for severe obesity, but recovery is often complicated by pain, nausea, and high opioid use. This systematic review and meta-analysis (SRMA) evaluates the role of erector spinae plane block (ESPB) in reducing pain, opioid consumption, and postoperative nausea and vomiting (PONV) after bariatric surgery.</p> Methods <p>Electronic databases were systematically searched from their inception to March 2025 for randomized controlled trials (RCTs) assessing bilateral ESPB in adults undergoing bariatric surgery. This review included studies which compared ESPB to a control group and reported at least one postoperative outcome. The primary outcome was resting pain at 6&#xa0;h and 24&#xa0;h. The mean difference (MD) and 95% confidence interval (CI) were calculated for each study and pooled using a random-effects model. The meta-regression and trial sequential analysis were performed to evaluate the impact of confounding variables and sample size on the pooled estimate. The risk of bias and certainty of evidence were assessed using the Cochrane Risk of Bias 2 (RoB 2) and Grading of Recommendations Assessment, Development, and Evaluation (GRADE) assessment tools.</p> Results <p>Twelve RCTs (n = 825; ESPB = 412, control = 413) were included. ESPB significantly reduced resting pain at 6&#xa0;h (MD: 1.79; 95% CI: 0.80 – 2.78; p = 0.0004) and 24&#xa0;h (MD: 1.09; 95% CI: 0.38–1.79; p = 0.002). Six RCTs (n = 509) reported lower movement-evoked pain at 6&#xa0;h (MD:1.28; 95% CI: 0.68–1.88; p &lt; 0.0001) and 24&#xa0;h (MD: 0.79; 95% CI: 0.44–1.14; p &lt; 0.0001). Nine RCTs (n = 673) showed reduced 24-h opioid consumption (MD: 9.0; 95% CI: 2.72 to 15.27, P = 0.005). Five RCTs (n = 448) reported a lower incidence of PONV with ESPB (Risk Ratio: 1.47; 95% CI: 1.08–1.98, p = 0.01). Meta-regression to adjust for baseline confounding factors and trial sequential analysis did not materially alter the results. The risk of bias was low, and the certainty of evidence was rated as moderate to low.</p> Conclusion <p>This SRMA of RCTs demonstrates that ESPB may significantly reduce postoperative pain, 24-h postoperative opioid consumption, and PONV compared to control in patients undergoing bariatric surgery. However, further RCTs with adequate power, unified protocols, and clearly defined endpoints are warranted.</p>

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Efficacy of Erector Spinae Block on Postoperative Outcomes in Bariatric Surgery Patients: A Systematic Review, Meta-Regression, and Trial-Sequential Analysis of Randomized Controlled Trials

  • 期刊论文

  • 发表日期：

    2026年5月7日

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  • Vitaliy Voznyy,
  • Salem Abu Al-Burak,
  • Yamini Subramani,
  • Mouad Elganga,
  • Alla Iansavitchene,
  • Lee-Anne Fochesato,
  • Priyanka Singh,
  • Harley Williams,
  • Christopher Harle,
  • Mahesh Nagappa

摘要

Background

Bariatric surgery is effective for severe obesity, but recovery is often complicated by pain, nausea, and high opioid use. This systematic review and meta-analysis (SRMA) evaluates the role of erector spinae plane block (ESPB) in reducing pain, opioid consumption, and postoperative nausea and vomiting (PONV) after bariatric surgery.

Methods

Electronic databases were systematically searched from their inception to March 2025 for randomized controlled trials (RCTs) assessing bilateral ESPB in adults undergoing bariatric surgery. This review included studies which compared ESPB to a control group and reported at least one postoperative outcome. The primary outcome was resting pain at 6 h and 24 h. The mean difference (MD) and 95% confidence interval (CI) were calculated for each study and pooled using a random-effects model. The meta-regression and trial sequential analysis were performed to evaluate the impact of confounding variables and sample size on the pooled estimate. The risk of bias and certainty of evidence were assessed using the Cochrane Risk of Bias 2 (RoB 2) and Grading of Recommendations Assessment, Development, and Evaluation (GRADE) assessment tools.

Results

Twelve RCTs (n = 825; ESPB = 412, control = 413) were included. ESPB significantly reduced resting pain at 6 h (MD: 1.79; 95% CI: 0.80 – 2.78; p = 0.0004) and 24 h (MD: 1.09; 95% CI: 0.38–1.79; p = 0.002). Six RCTs (n = 509) reported lower movement-evoked pain at 6 h (MD:1.28; 95% CI: 0.68–1.88; p < 0.0001) and 24 h (MD: 0.79; 95% CI: 0.44–1.14; p < 0.0001). Nine RCTs (n = 673) showed reduced 24-h opioid consumption (MD: 9.0; 95% CI: 2.72 to 15.27, P = 0.005). Five RCTs (n = 448) reported a lower incidence of PONV with ESPB (Risk Ratio: 1.47; 95% CI: 1.08–1.98, p = 0.01). Meta-regression to adjust for baseline confounding factors and trial sequential analysis did not materially alter the results. The risk of bias was low, and the certainty of evidence was rated as moderate to low.

Conclusion

This SRMA of RCTs demonstrates that ESPB may significantly reduce postoperative pain, 24-h postoperative opioid consumption, and PONV compared to control in patients undergoing bariatric surgery. However, further RCTs with adequate power, unified protocols, and clearly defined endpoints are warranted.