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Objectives <p>Obesity is a significant health problem with increasing prevalence worldwide and is associated with numerous comorbidities. In this prospective controlled study, the relationship between changes in platelet-to-lymphocyte ratio(PLR), neutrophil-to-lymphocyte ratio(NLR), and pan-immune-inflammation value(PIV)-calculated from complete blood count parameters on the preoperative day and the first postoperative day-and early major surgical complications following laparoscopic sleeve gastrectomy(LSG) was investigated.</p> Materials and Methods <p>Patients scheduled for LSG due to morbid obesity at the Department of General Surgery, Kahramanmaraş Sütçü İmam University, and Elazig Private Eastern Anatolia Hospital were prospectively included in the study. Preoperative and postoperative (24-hour) complete blood count (CBC) parameters were recorded, including white blood cell count (WBC), neutrophil count, lymphocyte count, monocyte count, and platelet count. PLR, NLR, and PIV were manually calculated. Patients were divided into two groups based on whether postoperative complications developed.</p> Results <p>In the preoperative period, significant differences were observed in WBC count, neutrophil count, and PIV values between patients with and without complications (<i>p</i> = 0.001, <i>p</i> &lt; 0.001, and <i>p</i> &lt; 0.001, respectively). In the postoperative period, significant differences were found between the two groups in WBC count, neutrophil count, platelet count, PLR, NLR, and PIV (<i>p</i> = 0.001, <i>p</i> &lt; 0.001, <i>p</i> &lt; 0.001, <i>p</i> = 0.047, <i>p</i> = 0.001, and <i>p</i> &lt; 0.001, respectively). When preoperative and postoperative values were compared, NLR, PLR, and PIV showed a statistically significant increase (<i>p</i> = 0.001, <i>p</i> &lt; 0.001, and <i>p</i> &lt; 0.001, respectively).</p> Conclusion <p>Our study demonstrated that among inflammatory markers calculated from CBC parameters, the PIV-assessing the overall immune-inflammatory response-provides higher specificity and sensitivity than NLR and PLR in predicting early postoperative major complications following LSG.</p>

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Pan-Immune Inflammation Value in Detecting Perioperative Complications in Patients Undergoing Laparoscopic Sleeve Gastrectomy: A Prospective Cohort Study

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年3月27日

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  • Nizamettin KUTLUER,
  • Ali AKSU,
  • Mehmet Buğra BOZAN,
  • Hakan AYYILDIZ,
  • Ayşe AZAK BOZAN,
  • Ali İŞLER,
  • Ali ÖZKÖMEÇ,
  • Mehmet Fatih EBİLOĞLU,
  • Muhammed ALKAN,
  • Onur AĞ,
  • Burak GÜNEŞ,
  • Cüneyt KIRKIL

摘要

Objectives

Obesity is a significant health problem with increasing prevalence worldwide and is associated with numerous comorbidities. In this prospective controlled study, the relationship between changes in platelet-to-lymphocyte ratio(PLR), neutrophil-to-lymphocyte ratio(NLR), and pan-immune-inflammation value(PIV)-calculated from complete blood count parameters on the preoperative day and the first postoperative day-and early major surgical complications following laparoscopic sleeve gastrectomy(LSG) was investigated.

Materials and Methods

Patients scheduled for LSG due to morbid obesity at the Department of General Surgery, Kahramanmaraş Sütçü İmam University, and Elazig Private Eastern Anatolia Hospital were prospectively included in the study. Preoperative and postoperative (24-hour) complete blood count (CBC) parameters were recorded, including white blood cell count (WBC), neutrophil count, lymphocyte count, monocyte count, and platelet count. PLR, NLR, and PIV were manually calculated. Patients were divided into two groups based on whether postoperative complications developed.

Results

In the preoperative period, significant differences were observed in WBC count, neutrophil count, and PIV values between patients with and without complications (p = 0.001, p < 0.001, and p < 0.001, respectively). In the postoperative period, significant differences were found between the two groups in WBC count, neutrophil count, platelet count, PLR, NLR, and PIV (p = 0.001, p < 0.001, p < 0.001, p = 0.047, p = 0.001, and p < 0.001, respectively). When preoperative and postoperative values were compared, NLR, PLR, and PIV showed a statistically significant increase (p = 0.001, p < 0.001, and p < 0.001, respectively).

Conclusion

Our study demonstrated that among inflammatory markers calculated from CBC parameters, the PIV-assessing the overall immune-inflammatory response-provides higher specificity and sensitivity than NLR and PLR in predicting early postoperative major complications following LSG.