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Background <p>Metabolic and bariatric surgery (MBS) is an effective treatment for obesity, but selecting the optimal technique remains challenging. One Anastomosis Gastric Bypass (OAGB) and Single Anastomosis Duodeno-Ileal with Sleeve Gastrectomy (SADI-S) are increasingly used, yet direct comparisons are scarce.</p> Objectives <p>To compare 30-day outcomes of OAGB and SADI-S in patients with a BMI of 45–50&#xa0;kg/m², focusing on safety and short-term efficacy within the OASIS trial.</p> Methods <p>In this randomized, single-blind trial, 89 patients underwent laparoscopic OAGB (<i>n</i> = 48) or SADI-S (<i>n</i> = 41). The primary endpoint is 5-year weight loss; this manuscript reports a planned 30-day safety analysis. Complications were graded using the Clavien-Dindo scale. Secondary outcomes included operative time, hospital stay, and early weight loss.</p> Results <p>Severe complications (Clavien-Dindo ≥ IIIb) occurred in 7.3% of SADI-S and 2.1% of OAGB patients (<i>p</i> = 0.33). Reoperations were also more common in SADI-S (7.3% vs. 2.1%; <i>p</i> = 0.33). Operative time was significantly longer for SADI-S (103.8 ± 18.4 vs. 82.2 ± 23.9&#xa0;min; <i>p</i> &lt; 0.001). No significant differences were found in early weight loss or comorbidity resolution. No 30-day mortality was recorded.</p> Conclusions <p>OAGB was associated with fewer complications and shorter operative times compared to SADI-S, although differences in severe complications and reoperations were not statistically significant. Long-term data are needed to fully evaluate outcomes.</p>

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Short-term Safety of one Anastomosis Gastric Bypass (OAGB) Versus Single Anastomosis Duodeno-Ileal Bypass with Sleeve Gastrectomy (SADI-S): 30-day Results from the OASIS trial

  • 期刊论文

  • 发表日期：

    2026年2月28日

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  • Ruth Lopez-Gonzalez,
  • Sergi Sanchez-Cordero,
  • Rodrigo Hermoza,
  • Jordi Pujol-Gebelli

摘要

Background

Metabolic and bariatric surgery (MBS) is an effective treatment for obesity, but selecting the optimal technique remains challenging. One Anastomosis Gastric Bypass (OAGB) and Single Anastomosis Duodeno-Ileal with Sleeve Gastrectomy (SADI-S) are increasingly used, yet direct comparisons are scarce.

Objectives

To compare 30-day outcomes of OAGB and SADI-S in patients with a BMI of 45–50 kg/m², focusing on safety and short-term efficacy within the OASIS trial.

Methods

In this randomized, single-blind trial, 89 patients underwent laparoscopic OAGB (n = 48) or SADI-S (n = 41). The primary endpoint is 5-year weight loss; this manuscript reports a planned 30-day safety analysis. Complications were graded using the Clavien-Dindo scale. Secondary outcomes included operative time, hospital stay, and early weight loss.

Results

Severe complications (Clavien-Dindo ≥ IIIb) occurred in 7.3% of SADI-S and 2.1% of OAGB patients (p = 0.33). Reoperations were also more common in SADI-S (7.3% vs. 2.1%; p = 0.33). Operative time was significantly longer for SADI-S (103.8 ± 18.4 vs. 82.2 ± 23.9 min; p < 0.001). No significant differences were found in early weight loss or comorbidity resolution. No 30-day mortality was recorded.

Conclusions

OAGB was associated with fewer complications and shorter operative times compared to SADI-S, although differences in severe complications and reoperations were not statistically significant. Long-term data are needed to fully evaluate outcomes.