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Background <p>There is a continuous upward trend in the number of repeated metabolic bariatric surgeries (MBS) performed worldwide. In some cases, patients undergo a third or even higher-order MBS, yet there is a paucity of data regarding the clinical profiles of this population. This study aims to characterize the surgical history, anthropometric outcomes, and mental health profiles of patients seeking a third or higher-order MBS.</p> Methods <p>Between 2016 and 2021, candidates for a third or higher-order MBS underwent comprehensive evaluations by a clinical psychologist and a registered dietitian. Sociodemographic, psychological, and health data were collected from medical records, with psychological interviews conducted using a semi-structured DSM-5-based format.</p> Results <p>Data was collected from 99 candidates; 84 planned a third MBS, 14 a fourth, and one a fifth. The mean age and BMI were 47.8 years and 41.7 kg/m<sup>2</sup>, respectively, and 80.8% were women. Most participants (95%) had undergone banding-based procedures as their primary MBS, and about 70% were converted to sleeve gastrectomy as a secondary MBS. Excess weight loss was lower after secondary compared to primary MBS (54.3 ± 47.4% vs. 64.9 ± 35.4%). High rates of psychopathology were observed, including depression (58.8%), anxiety (35.8%), post-traumatic stress disorder (58.5%), and 23.7% reported on psychiatric medication use.</p> Conclusions <p>This study illuminates a distinctive population of candidates seeking a third or higher-order BMS, revealing a notable prevalence of psychopathologies within this group. The findings underscore the importance of conducting further prospective studies to delve into clinical features associated with repeatable BMS.</p> Key Points <p>• Third or higher-order MBS are increasingly performed worldwide.</p> <p>• Patients seeking repeated MBS often present with complex surgical histories.</p> <p>• Weight loss outcomes were less favorable after secondary vs. primary MBS.</p> <p>• High prevalence of psychopathology was observed in this unique population.</p>

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Phenotyping of Patients Seeking Third or Higher-Order Metabolic Bariatric Surgery

  • 期刊论文

  • 发表日期：

    2026年1月16日

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  • Michal Zaichyk-Segal,
  • Orit Yogev,
  • Chaya Chweiger,
  • Galit Goldzak-Kunik,
  • Roni Elran-Barak,
  • Shiri Sherf-Dagan

摘要

Background

There is a continuous upward trend in the number of repeated metabolic bariatric surgeries (MBS) performed worldwide. In some cases, patients undergo a third or even higher-order MBS, yet there is a paucity of data regarding the clinical profiles of this population. This study aims to characterize the surgical history, anthropometric outcomes, and mental health profiles of patients seeking a third or higher-order MBS.

Methods

Between 2016 and 2021, candidates for a third or higher-order MBS underwent comprehensive evaluations by a clinical psychologist and a registered dietitian. Sociodemographic, psychological, and health data were collected from medical records, with psychological interviews conducted using a semi-structured DSM-5-based format.

Results

Data was collected from 99 candidates; 84 planned a third MBS, 14 a fourth, and one a fifth. The mean age and BMI were 47.8 years and 41.7 kg/m2, respectively, and 80.8% were women. Most participants (95%) had undergone banding-based procedures as their primary MBS, and about 70% were converted to sleeve gastrectomy as a secondary MBS. Excess weight loss was lower after secondary compared to primary MBS (54.3 ± 47.4% vs. 64.9 ± 35.4%). High rates of psychopathology were observed, including depression (58.8%), anxiety (35.8%), post-traumatic stress disorder (58.5%), and 23.7% reported on psychiatric medication use.

Conclusions

This study illuminates a distinctive population of candidates seeking a third or higher-order BMS, revealing a notable prevalence of psychopathologies within this group. The findings underscore the importance of conducting further prospective studies to delve into clinical features associated with repeatable BMS.

Key Points

• Third or higher-order MBS are increasingly performed worldwide.

• Patients seeking repeated MBS often present with complex surgical histories.

• Weight loss outcomes were less favorable after secondary vs. primary MBS.

• High prevalence of psychopathology was observed in this unique population.