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Introduction <p>Roux-en-Y gastric bypass (RYGB) is an effective treatment for obesity and metabolic disorders. Co-administration of Spirulina (SP), a cyanobacterium of the genus Arthrospira <i>platensis</i>, accelerates weight loss and improves body composition. It is believed that supplementing with 2&#xa0;g of SP for 30 days is safe and improves body composition in women undergoing RYGB.</p> Objective <p>To evaluate the effects of SP supplementation on body composition and blood parameters of women undergoing RYGB.</p> Methods <p>Forty-nine women indicated for RYGB were divided into two groups: SP (<i>n</i> =25), which received 2 g of SP, and placebo (PL, <i>n</i> =24), which received 2 g of starch. The parameters were analyzed at baseline and after 30 days of post-RYGB intervention. ANCOVA and chi-square were performed in SPSS (version 25), with a significance level of 5% (<i>p</i> &lt; 0.05).</p> Results <p>Thirty patients (SP, <i>n</i> = 15; PL, <i>n</i> = 15) with a mean age of 42.82±9.35 years concluded the study. Post-RYGB, the SP group exhibited significant decreases in arm circumference (<i>p</i> = 0.035), fat mass (<i>p</i> = 0.033), muscle mass loss (<i>p</i> &lt;0.001), body fat (<i>p</i> = 0.018), subcutaneous fat (<i>p</i> = 0.019), and blood urea levels (<i>p</i> = 0.042) compared to the PL group. The SP group had significantly more lean mass (<i>p</i> = 0.036) and skeletal muscle mass (<i>p</i> = 0.030), elevated BMR (<i>p</i> = 0.034), and a higher percentage of fat mass loss (<i>p</i> &lt;0.001), along with increased levels of body protein (<i>p</i> = 0.028) and hydration (<i>p</i> = 0.037) in comparison to the PL group.</p> Conclusion <p>Supplementation with 2 g of SP for 30 days was safe, improved body composition, and decreased urea levels in women with obesity undergoing RYGB.</p>

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Postoperative Spirulina Platensis Supplementation Optimizes Body Composition Improvement without Adverse Effects in Women Undergoing Gastric Bypass: a Pilot Study Randomized and Placebo-Controlled

  • 期刊论文

  • 发表日期：

    2025年11月26日

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  • Paula Caroline de Almeida,
  • Thiago da Rosa Lima,
  • Eudes Thiago Pereira Avila,
  • Gabriel Abreu Brito,
  • Natália Ost Malheios,
  • Régis Vilela Leal,
  • Eduardo Rodrigues Alves Junior,
  • Gunther Peres Pimenta,
  • James Wilfred Navalta,
  • Amilcar Sabino Damazo

摘要

Introduction

Roux-en-Y gastric bypass (RYGB) is an effective treatment for obesity and metabolic disorders. Co-administration of Spirulina (SP), a cyanobacterium of the genus Arthrospira platensis, accelerates weight loss and improves body composition. It is believed that supplementing with 2 g of SP for 30 days is safe and improves body composition in women undergoing RYGB.

Objective

To evaluate the effects of SP supplementation on body composition and blood parameters of women undergoing RYGB.

Methods

Forty-nine women indicated for RYGB were divided into two groups: SP (n =25), which received 2 g of SP, and placebo (PL, n =24), which received 2 g of starch. The parameters were analyzed at baseline and after 30 days of post-RYGB intervention. ANCOVA and chi-square were performed in SPSS (version 25), with a significance level of 5% (p < 0.05).

Results

Thirty patients (SP, n = 15; PL, n = 15) with a mean age of 42.82±9.35 years concluded the study. Post-RYGB, the SP group exhibited significant decreases in arm circumference (p = 0.035), fat mass (p = 0.033), muscle mass loss (p <0.001), body fat (p = 0.018), subcutaneous fat (p = 0.019), and blood urea levels (p = 0.042) compared to the PL group. The SP group had significantly more lean mass (p = 0.036) and skeletal muscle mass (p = 0.030), elevated BMR (p = 0.034), and a higher percentage of fat mass loss (p <0.001), along with increased levels of body protein (p = 0.028) and hydration (p = 0.037) in comparison to the PL group.

Conclusion

Supplementation with 2 g of SP for 30 days was safe, improved body composition, and decreased urea levels in women with obesity undergoing RYGB.