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<p>This systematic review and meta-analysis aim to comprehensively assess the effect of bariatric surgery on thyroid function. A search of PubMed, Web of Science, and Scopus databases was performed until 19 November 2024. Sixty-seven studies with 8,754 total patients included in our analysis showed a significant decrease in pooled standard mean differences (SMD) of serum TSH, total T3, and free T3 levels post operation (<i>p</i>-value &lt; 0.05). Our analysis showed a significant marginal decrease in total T4 level by subgroup analysis in overall region and surgery (<i>p</i>-value &lt; 0.05) whereas free T4 didn’t change significantly (<i>p</i>-value &gt; 0.05). Subgroup analyses, meta-regression, and publication bias analysis were done. Based on this meta-analysis, significant reduction of TSH, marginally total T4, Total T3, and free T3 levels, as well as non-significant change of FT4 are expected following bariatric surgery.</p>

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Thyroid function post-bariatric surgery: an updated systematic review and meta-analysis

  • 期刊论文

  • 发表日期：

    2025年11月26日

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  • Niloofar Seighali,
  • Alireza Khodayari Javazm,
  • Sina Kazemian,
  • Mohammadhasan Matin,
  • Hedie Soltani,
  • Mahya Beikmohammdi,
  • Amirhossein Mehrpour,
  • Mahmood Bakhtiyari

摘要

This systematic review and meta-analysis aim to comprehensively assess the effect of bariatric surgery on thyroid function. A search of PubMed, Web of Science, and Scopus databases was performed until 19 November 2024. Sixty-seven studies with 8,754 total patients included in our analysis showed a significant decrease in pooled standard mean differences (SMD) of serum TSH, total T3, and free T3 levels post operation (p-value < 0.05). Our analysis showed a significant marginal decrease in total T4 level by subgroup analysis in overall region and surgery (p-value < 0.05) whereas free T4 didn’t change significantly (p-value > 0.05). Subgroup analyses, meta-regression, and publication bias analysis were done. Based on this meta-analysis, significant reduction of TSH, marginally total T4, Total T3, and free T3 levels, as well as non-significant change of FT4 are expected following bariatric surgery.