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Background <p>Weight loss and improvement in health-related quality of life (HRQoL) following metabolic bariatric surgery (MBS) are well documented. However, there is varied and inconclusive data on postoperative gastrointestinal symptoms.</p> Methods <p>A prospectively maintained database of patients in a regional hospital undergoing laparoscopic sleeve gastrectomy (LSG), Roux-en-Y gastric bypass (RYGB) and one-anastomosis gastric bypass (OAGB) between March 2018 and August 2019 was retrospectively analysed. Gastrointestinal symptoms and HRQoL were measured over 2&#xa0;years using the Structured Assessment of Gastrointestinal Symptoms Scale (SAGIS) and Short Form 36 (SF-36) standardised health questionnaires, respectively.</p> Results <p>A total of 203 patients were included for analysis. There was an improvement in median total symptom burden score from 5.5 to 4.0 at 24&#xa0;months (<i>p</i> = 0.010). Constipation scores did not change. Nausea and vomiting worsened in the first 6&#xa0;months (<i>p</i> &lt; 0.001) and then improved back to baseline by 24&#xa0;months (<i>p</i> = 0.003). Diarrhoea and discomfort scores improved from baseline to 24&#xa0;months (<i>p</i> = 0.022). Epigastric pain improved from baseline to 24&#xa0;months (<i>p</i> = 0.021). Median reflux score did not change between 0 and 6&#xa0;months and then improved to significantly better than baseline at 24&#xa0;months (<i>p</i> = 0.040). All three surgeries demonstrated sustained weight loss to 24&#xa0;months. Overall HRQoL and each of the eight domains significantly improved post-surgery.</p> Conclusion <p>There was an overall improvement in gastrointestinal symptoms post-surgery. The data reaffirmed sustained weight loss and improvement in HRQoL post MBS.</p>

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Gastrointestinal Symptoms and Health-Related Quality of Life Following Metabolic Bariatric Surgery: A Prospective Cohort Study

  • 期刊论文

  • 发表日期：

    2025年6月24日

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  • Lee Shyang Kyang,
  • Imogen Hines,
  • Emma Thomas,
  • Alexa Seal,
  • Richard Harrison,
  • Denbigh Simond,
  • Nicholas Williams

摘要

Background

Weight loss and improvement in health-related quality of life (HRQoL) following metabolic bariatric surgery (MBS) are well documented. However, there is varied and inconclusive data on postoperative gastrointestinal symptoms.

Methods

A prospectively maintained database of patients in a regional hospital undergoing laparoscopic sleeve gastrectomy (LSG), Roux-en-Y gastric bypass (RYGB) and one-anastomosis gastric bypass (OAGB) between March 2018 and August 2019 was retrospectively analysed. Gastrointestinal symptoms and HRQoL were measured over 2 years using the Structured Assessment of Gastrointestinal Symptoms Scale (SAGIS) and Short Form 36 (SF-36) standardised health questionnaires, respectively.

Results

A total of 203 patients were included for analysis. There was an improvement in median total symptom burden score from 5.5 to 4.0 at 24 months (p = 0.010). Constipation scores did not change. Nausea and vomiting worsened in the first 6 months (p < 0.001) and then improved back to baseline by 24 months (p = 0.003). Diarrhoea and discomfort scores improved from baseline to 24 months (p = 0.022). Epigastric pain improved from baseline to 24 months (p = 0.021). Median reflux score did not change between 0 and 6 months and then improved to significantly better than baseline at 24 months (p = 0.040). All three surgeries demonstrated sustained weight loss to 24 months. Overall HRQoL and each of the eight domains significantly improved post-surgery.

Conclusion

There was an overall improvement in gastrointestinal symptoms post-surgery. The data reaffirmed sustained weight loss and improvement in HRQoL post MBS.