Scholarlink

<p>We aimed to investigate the effect of primary Roux-en-Y gastric bypass (RYGB) on gastro-oesophageal reflux disease (GORD)&#xa0;in patients with obesity. A systematic review was performed using MEDLINE, Embase, Emcare, and CINAHL databases for studies that reported on GORD outcomes following RYGB&#xa0;for obesity (January 2000–November 2023). Fourteen studies with 28,027 patients underwent RYGB, with pooled analysis demonstrating a 47% (95% CI 34.0–59.0; <i>p</i> ≤ 0.005) improvement in GORD symptoms and 4.5% (95% CI 1.7–7.2; <i>p</i> ≤ 0.005) with worsening/new onset GORD. Postoperative DeMeester score improved by 16.49 points (95% CI 0.2–32.7; <i>p</i> ≤&#xa0;0.005) and 79.4% (95% CI 68.7–90.1; <i>p</i> = 0.01) completely discontinued proton-pump inhibitor therapy during the follow-up period. RYGB surgery may potentially improve GORD symptoms in patients with obesity, with an overall low incidence of de novo GORD.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Gastro-Oesophageal Reflux Disease Outcomes Following Roux-en-Y Gastric Bypass Surgery in Patients with Obesity: A Systematic Review and Meta-analysis

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年4月24日

查看全文
  • Narek Sargsyan,
  • Iihan Ali,
  • Christopher Namgoong,
  • Bibek Das,
  • Matyas Fehervari,
  • Michael G. Fadel

摘要

We aimed to investigate the effect of primary Roux-en-Y gastric bypass (RYGB) on gastro-oesophageal reflux disease (GORD) in patients with obesity. A systematic review was performed using MEDLINE, Embase, Emcare, and CINAHL databases for studies that reported on GORD outcomes following RYGB for obesity (January 2000–November 2023). Fourteen studies with 28,027 patients underwent RYGB, with pooled analysis demonstrating a 47% (95% CI 34.0–59.0; p ≤ 0.005) improvement in GORD symptoms and 4.5% (95% CI 1.7–7.2; p ≤ 0.005) with worsening/new onset GORD. Postoperative DeMeester score improved by 16.49 points (95% CI 0.2–32.7; p ≤ 0.005) and 79.4% (95% CI 68.7–90.1; p = 0.01) completely discontinued proton-pump inhibitor therapy during the follow-up period. RYGB surgery may potentially improve GORD symptoms in patients with obesity, with an overall low incidence of de novo GORD.