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Background <p>Several studies have documented a beneficial short-term effect on lipid profile after Roux-en-Y gastric bypass (RYGB), but there is limited data on long-term changes.</p> Objectives <p>To describe long-term (&gt; 10&#xa0;years) changes in lipid profile after RYGB and to explore the relationship of lipid changes to changes in weight and baseline and demographic parameters.</p> Methods <p>The BAROBS study is a prospective observational study post RYGB conducted at three different hospitals. Surgical procedures were performed between 2003 and 2009, and the collection of data was in 2018–2020. Data on lipid profile, weight, body mass index (BMI), percentage of total weight loss (%TWL), and pre- and postoperative type II diabetes mellitus (DMII) was collected at baseline, 1–2, 5, and 10&#xa0;years post-surgery and was available for 314 of 546 patients in the study.</p> Results <p>The mean (SD) follow-up was 11.5(± 1.5) years, with a mean reduction of 11.7% for LDL, 29.7% for TG, and 7.7% for total cholesterol compared to baseline. Except for HDL and total-/HDL-cholesterol-ratio, all lipid variables reached their greatest change after 1–2&#xa0;years with an attenuation of changes at end of study. HDL and total-/HDL-cholesterol-ratio had stable values from 5 to 10&#xa0;years post-surgery. Lipid profile improved more in patients with greater weight loss. There was a 59% reduction in DMII at end of study, and there was a significant relation between preoperative DMII and long-term lipid values.</p> Conclusion <p>There is an improvement of all lipid parameters after 10&#xa0;years post RYGB related to both the magnitude of weight loss and the presence of DMII.</p> Graphical Abstract <p></p>

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Lipid Changes 10–15 Years After Roux-en-Y Gastric Bypass: A Prospective Observational Study

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年1月15日

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  • Eirin Rosø Barkhall,
  • Johanne Tro,
  • Jorunn Sandvik,
  • Siren Nymo,
  • Bård Kulseng,
  • Gjermund Johnsen,
  • Dag Arne Lihaug Hoff,
  • Torstein Hole

摘要

Background

Several studies have documented a beneficial short-term effect on lipid profile after Roux-en-Y gastric bypass (RYGB), but there is limited data on long-term changes.

Objectives

To describe long-term (> 10 years) changes in lipid profile after RYGB and to explore the relationship of lipid changes to changes in weight and baseline and demographic parameters.

Methods

The BAROBS study is a prospective observational study post RYGB conducted at three different hospitals. Surgical procedures were performed between 2003 and 2009, and the collection of data was in 2018–2020. Data on lipid profile, weight, body mass index (BMI), percentage of total weight loss (%TWL), and pre- and postoperative type II diabetes mellitus (DMII) was collected at baseline, 1–2, 5, and 10 years post-surgery and was available for 314 of 546 patients in the study.

Results

The mean (SD) follow-up was 11.5(± 1.5) years, with a mean reduction of 11.7% for LDL, 29.7% for TG, and 7.7% for total cholesterol compared to baseline. Except for HDL and total-/HDL-cholesterol-ratio, all lipid variables reached their greatest change after 1–2 years with an attenuation of changes at end of study. HDL and total-/HDL-cholesterol-ratio had stable values from 5 to 10 years post-surgery. Lipid profile improved more in patients with greater weight loss. There was a 59% reduction in DMII at end of study, and there was a significant relation between preoperative DMII and long-term lipid values.

Conclusion

There is an improvement of all lipid parameters after 10 years post RYGB related to both the magnitude of weight loss and the presence of DMII.

Graphical Abstract