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<p>There is growing scientific interest in plant-derived proteins due to their superior nutritional profile and potential health-promoting properties. <i>Moringa oleifera</i> seeds extract (MOE), <i>M. oleifera</i> protein isolate (MOPi), and its hydrolysate (MOPh) were investigated for their nutritional composition, bioactive compounds, antioxidant properties in vitro and in vivo, and their effects on body metabolism. Moringa seeds contained approximately 31.6% protein, 29.34% lipids, 9.22% carbohydrates, and 8.2% ash. MOE, MOPi, and MOPh exhibited strong antioxidant activity. MOE, MOPi and MOPh significantly reduced body weight and feed efficiency in obese Wistar rat model. Additionally, MOE, MOPi and MOPh improved lipid profiles by lowering LDL cholesterol and triglycerides and elevating HDL levels. The results underscore the high value of Moringa seeds biomolecules (extract and biopeptides) as promising agents for addressing obesity, metabolic dysregulation, and oxidative imbalance, showing important potential on body metabolism.</p>

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Moringa oleifera seeds extract and protein hydrolysate as anti-obesity candidates in high-fat-diet rats model

  • 期刊论文

  • 发表日期：

    2026年6月2日

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  • Maram Mezhoudi,
  • Sulaiman A. Alsalamah,
  • Ola Abdelhedi,
  • Walid Elfalleh,
  • Hamdi Bendif,
  • Nacim Zouari,
  • Mourad Jridi

摘要

There is growing scientific interest in plant-derived proteins due to their superior nutritional profile and potential health-promoting properties. Moringa oleifera seeds extract (MOE), M. oleifera protein isolate (MOPi), and its hydrolysate (MOPh) were investigated for their nutritional composition, bioactive compounds, antioxidant properties in vitro and in vivo, and their effects on body metabolism. Moringa seeds contained approximately 31.6% protein, 29.34% lipids, 9.22% carbohydrates, and 8.2% ash. MOE, MOPi, and MOPh exhibited strong antioxidant activity. MOE, MOPi and MOPh significantly reduced body weight and feed efficiency in obese Wistar rat model. Additionally, MOE, MOPi and MOPh improved lipid profiles by lowering LDL cholesterol and triglycerides and elevating HDL levels. The results underscore the high value of Moringa seeds biomolecules (extract and biopeptides) as promising agents for addressing obesity, metabolic dysregulation, and oxidative imbalance, showing important potential on body metabolism.