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<p>The hepatoprotective activity of the grape pomace (GP) from ‘Pusa Navrang’ (PNGP) and ‘Bangalore Purple’ (BPGP) was investigated against paracetamol-induced hepatotoxicity. GP, a reservoir of antioxidants, aided in managing and restoring the hepatic cell damage. It optimized the serum liver enzymes like alanine aminotransferase (ALT), aspartate transaminase (AST), and alkaline phosphatase (ALP). Serum glucose, total bilirubin, and total protein levels were also optimized. Paracetamol elevated lipid peroxidation (LPO) and reduced glutathione (GSH). The administration of the standard drug (silymarin) and test compounds PNGP and BPGP normalized the levels of LPO and GSH. Effective restoration of the liver’s antioxidant enzymes, like superoxide dismutase (SOD), peroxidase (POD), and catalase (CAT) was also observed. Study results revealed that PNGP and BPGP at 400&#xa0;mg/kg showed better hepatoprotective activity close to the standard drug silymarin, while better results were obtained in the PNGP-treated groups. Multivariate analysis confirmed grape pomace potential in mitigating liver injury.</p>

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Comprehensive assessment of the hepatoprotective activity of grape pomace against paracetamol-induced liver damage in Swiss albino mice

  • 期刊论文

  • 发表日期：

    2025年12月23日

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  • Sindhu PM,
  • Shruti Sethi,
  • V. M. Chandrashekar,
  • Chavlesh Kumar,
  • Alka Joshi,
  • Arpan Bhowmik,
  • Anand Balappa Kalakonnavar,
  • Lekshmi SG,
  • Prasoon Gunjan,
  • Anurag Saurabh

摘要

The hepatoprotective activity of the grape pomace (GP) from ‘Pusa Navrang’ (PNGP) and ‘Bangalore Purple’ (BPGP) was investigated against paracetamol-induced hepatotoxicity. GP, a reservoir of antioxidants, aided in managing and restoring the hepatic cell damage. It optimized the serum liver enzymes like alanine aminotransferase (ALT), aspartate transaminase (AST), and alkaline phosphatase (ALP). Serum glucose, total bilirubin, and total protein levels were also optimized. Paracetamol elevated lipid peroxidation (LPO) and reduced glutathione (GSH). The administration of the standard drug (silymarin) and test compounds PNGP and BPGP normalized the levels of LPO and GSH. Effective restoration of the liver’s antioxidant enzymes, like superoxide dismutase (SOD), peroxidase (POD), and catalase (CAT) was also observed. Study results revealed that PNGP and BPGP at 400 mg/kg showed better hepatoprotective activity close to the standard drug silymarin, while better results were obtained in the PNGP-treated groups. Multivariate analysis confirmed grape pomace potential in mitigating liver injury.