<p>Honey is an excellent source of a variety of chemical compounds and elements vital for human consumption. But changes in environmental conditions, anthropogenic pollution as well as deliberative adulteration practices might be altering the properties and thereby degrading the quality of honey. This study focuses on 72 mangrove honey samples collected from various coastal regions of the Indian Sundarbans to assess their physicochemical and biochemical parameters, and multi-elemental contents to determine their quality in the context of suitability for human consumption. Only 28% of wild honey samples (<i>n</i> = 35) and 11% of apiary honey samples (<i>n</i> = 37) were able to meet the honey specification made by food safety standards. Generalised Linear Model (GLM) showed a significant difference in overall quality between the wild and apiary honey samples. The Principal Component Analysis (PCA) suggested that the physical characteristics of the honey samples were mostly preserved while the concentrations of the essential elements were mostly responsible for variation between the samples. Macro and micro essential elements in all mangrove honey samples were within the limit made by food safety standards. This study found only 18% of total honey samples (<i>n</i> = 72) collected from Indian Sundarbans are suitable for human consumption. This study suggest that the honey collection methodology should be standardized and ecologically sustainable. To verify that the harvested honey is safe for human consumption or not, rigorous testing is required.</p>