Scholarlink

<p>Bioactive compounds occurring in nature are sensitive to external conditions; hence, it is necessary to entrap them into delivery systems, such as liposomes. Using the Mozafari method, the phenolic extracts from the sweet lime peel (SP) were encapsulated. Zeta <b>(</b>ζ) potential, polydispersity index (PDI), and encapsulation efficiency (EE) were determined for three liposomal formulations: SP-L, Ch-SP-L (with 0.1-1% w/v chitosan), and P-Ch-SP-L (with 0.1-1% w/v pectin). The size of SP-L increased due to the biopolymer coatings, confirming the deposition of chitosan (0.25%) and pectin (0.5%) on the SP-L surface. The coatings caused a notable rise in EE, from 77.4% in SP-L to 82.1% in Ch-SP-L and 89.5% in P-Ch-SP-L. Because of the strong barrier provided by the P-Ch layer compared to chitosan alone, P-Ch-SP-L displayed better pH, ionic, and storage stability (85% and 74% at 4 and 25 ℃, respectively). Moreover, P-Ch-SP-L also showed high stability at the end of the stimulated intestinal digestion phase, with a low release rate (20.4%) compared to Ch-SP-L (32%) and SP-L (70.4%). Therefore, P-Ch could be deemed a promising coating for generating stable liposomes for the effective delivery of bioactive compounds.</p> Graphical abstract <p></p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Fabrication of sweet lime (Citrus limetta) peel extract loaded multilayered liposomes: characterization, structural stability, and in vitro digestion analysis

  • 期刊论文

  • 发表日期：

    2025年9月29日

查看全文
  • Manonmani Thiruvalluvan,
  • Barjinder Pal Kaur

摘要

Bioactive compounds occurring in nature are sensitive to external conditions; hence, it is necessary to entrap them into delivery systems, such as liposomes. Using the Mozafari method, the phenolic extracts from the sweet lime peel (SP) were encapsulated. Zeta (ζ) potential, polydispersity index (PDI), and encapsulation efficiency (EE) were determined for three liposomal formulations: SP-L, Ch-SP-L (with 0.1-1% w/v chitosan), and P-Ch-SP-L (with 0.1-1% w/v pectin). The size of SP-L increased due to the biopolymer coatings, confirming the deposition of chitosan (0.25%) and pectin (0.5%) on the SP-L surface. The coatings caused a notable rise in EE, from 77.4% in SP-L to 82.1% in Ch-SP-L and 89.5% in P-Ch-SP-L. Because of the strong barrier provided by the P-Ch layer compared to chitosan alone, P-Ch-SP-L displayed better pH, ionic, and storage stability (85% and 74% at 4 and 25 ℃, respectively). Moreover, P-Ch-SP-L also showed high stability at the end of the stimulated intestinal digestion phase, with a low release rate (20.4%) compared to Ch-SP-L (32%) and SP-L (70.4%). Therefore, P-Ch could be deemed a promising coating for generating stable liposomes for the effective delivery of bioactive compounds.

Graphical abstract