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<p>The extract of lichens <i>Caloplaca saxicola</i> (CS), <i>Xanthoria candelaria</i> (XC), and <i>Xanthoria elegans</i> (XE) were screened for Antioxidant And antimicrobial activities. Anthraquinone parietin was identified as the major compound in the extracts. The maximum concentration of parietin was in XE. Maximum scavenging activity was in the extracts of the XE. Extracts of CS, XC and XE exhibited 61.69%, 71.91% And 74.97% hydrogen peroxide scavenging activity. The extracts exhibited strong reducing power and superoxide anion radical scavenging activity. Fe<sup>2+</sup> could be chelated by CS, XC, and XE extracts in a concentration-dependent manner. The antioxidant activity of extracts showed dose dependence and increased with concentration of extracts. XE extract had the highest effect on <i>B. cereus</i> inoculated plates, with a mean zone of inhibition of 28.5 ± 1.2&#xa0;mm. The XE extracts MIC against <i>S. aureus</i> was determined to be 7.5 ± 0.1&#xa0;µg/mL, while for <i>B. cereus</i> it was found to be 6.0 ± 0.1&#xa0;µg/mL. Docking studies targeting the active site of human peroxiredoxin 5 and glucosamine-6-phosphate synthase were employed to explore the possible interactions of the parietin and standard compounds. The in vitro findings suggesting parietin as an antioxidant and antimicrobial agent were supported by computational analysis.</p>

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Antioxidant and antimicrobial potentials of Parietin producing lichens Caloplaca saxicola (Hoffm.), Xanthoria Candelaria (L.) th.fr. And Xanthoria elegans (L.) th.fr

  • 期刊论文

  • 发表日期：

    2025年10月4日

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  • Amit Gupta,
  • Ashish P. Singh,
  • Prashant R. Singh,
  • Rajeshwar P. Sinha

摘要

The extract of lichens Caloplaca saxicola (CS), Xanthoria candelaria (XC), and Xanthoria elegans (XE) were screened for Antioxidant And antimicrobial activities. Anthraquinone parietin was identified as the major compound in the extracts. The maximum concentration of parietin was in XE. Maximum scavenging activity was in the extracts of the XE. Extracts of CS, XC and XE exhibited 61.69%, 71.91% And 74.97% hydrogen peroxide scavenging activity. The extracts exhibited strong reducing power and superoxide anion radical scavenging activity. Fe2+ could be chelated by CS, XC, and XE extracts in a concentration-dependent manner. The antioxidant activity of extracts showed dose dependence and increased with concentration of extracts. XE extract had the highest effect on B. cereus inoculated plates, with a mean zone of inhibition of 28.5 ± 1.2 mm. The XE extracts MIC against S. aureus was determined to be 7.5 ± 0.1 µg/mL, while for B. cereus it was found to be 6.0 ± 0.1 µg/mL. Docking studies targeting the active site of human peroxiredoxin 5 and glucosamine-6-phosphate synthase were employed to explore the possible interactions of the parietin and standard compounds. The in vitro findings suggesting parietin as an antioxidant and antimicrobial agent were supported by computational analysis.