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<p>The field of taste detection faces significant challenges in both technological development and practical implementation, particularly concerning limitations in detection accuracy and sensitivity, difficulties in simulating the complexity of human taste perception, and insufficient sensor selectivity. Cell-based electrochemical taste sensors represent a promising biosensing technology. These sensors utilize living cells as the primary sensing element. Owing to their high biological correlation, they can capture complex biological responses in real-time based on external stimulus intensity, generating electrochemical signals that effectively mimic human taste perception. Unlike previous reviews, this work addresses a gap in the literature by comprehensively describing general strategies for constructing current cell-based taste sensors. The discussed cell-based electrochemical sensors are applicable for taste analysis in pharmaceuticals, food, and food additives. Key construction strategies reported include screening appropriate cell lines and receptor expression, selecting sensor platforms, modifying electrode materials, and transducing electrochemical signals. The favorable performance of these sensors in analyzing the taste of food and pharmaceuticals is highlighted. Currently, this technology predominantly enables only single-taste detection. Future advancements integrating the Internet of Things and Artificial Intelligence, alongside further optimization of sensor construction strategies, are envisioned to yield more efficient and cost-effective taste detection systems.</p>

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Development strategies and applications of cell-based electrochemical taste sensors

  • 期刊论文

  • 发表日期：

    2025年8月9日

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  • Xiaowei Huang,
  • Yuqing Qi,
  • Zhihua Li,
  • Ning Zhang,
  • Zhou Qin,
  • Liuzi Du,
  • Jiyong Shi,
  • Xiaobo Zou

摘要

The field of taste detection faces significant challenges in both technological development and practical implementation, particularly concerning limitations in detection accuracy and sensitivity, difficulties in simulating the complexity of human taste perception, and insufficient sensor selectivity. Cell-based electrochemical taste sensors represent a promising biosensing technology. These sensors utilize living cells as the primary sensing element. Owing to their high biological correlation, they can capture complex biological responses in real-time based on external stimulus intensity, generating electrochemical signals that effectively mimic human taste perception. Unlike previous reviews, this work addresses a gap in the literature by comprehensively describing general strategies for constructing current cell-based taste sensors. The discussed cell-based electrochemical sensors are applicable for taste analysis in pharmaceuticals, food, and food additives. Key construction strategies reported include screening appropriate cell lines and receptor expression, selecting sensor platforms, modifying electrode materials, and transducing electrochemical signals. The favorable performance of these sensors in analyzing the taste of food and pharmaceuticals is highlighted. Currently, this technology predominantly enables only single-taste detection. Future advancements integrating the Internet of Things and Artificial Intelligence, alongside further optimization of sensor construction strategies, are envisioned to yield more efficient and cost-effective taste detection systems.