Scholarlink

<p>Ochratoxin A (OTA), a secondary metabolic product, is one of the most vicious mycotoxins produced by a large species of filamentous fungi that are often associated with different grains and have tolerance against unfavorable conditions. It has a fatal effect on the health of mammals through its direct impact on the efficiency and functions of several body organs. In this study, 153 random assorted samples of barley, yellow corn, soybean, and wheat grains were collected from four different regions of Saudi Arabia. The highest OTA contamination in barley, yellow corn, soybean and wheat grains was 53.0, 210.6, 146.6, and 51.6&#xa0;µg kg<sup>− 1</sup>, respectively. While, the highest average of OTA was recorded in yellow corn grains as 156.67&#xa0;µg kg<sup>− 1</sup> and the lowest as 13.3&#xa0;µg kg<sup>− 1</sup> in barley. <i>Aspergillus ochraceus</i> and <i>A. carbonarius</i> were identified as ochratoxigenic species by BIOLOG technique. The highest relative density (RD %) was recorded for <i>A. ochraceus</i> in yellow corn grains as 8.33% and decreased in barley, soybean and wheat as 5.56, 6.90, and 7.69%, respectively. Clinoptilolite binder reduced OTA concentration in all tested isolates but to varying rates, under recommended dose. The highest reduction was 26.6% with <i>A. ochraceus</i>, while reached 30% with <i>A. carbonarius</i> after 21 days. Mice were fed on yellow corn grains contaminated artificially by mild ochratoxigenic isolate (RIY-C1) resulted in increase of OTA to 5.65, 17.84 and 19.25&#xa0;µg kg<sup>− 1</sup> after 15, 30, and 45 days, respectively. In conjunction with OTA increasing in mice-feed, the activity of liver and kidney function as Alanine Aminotransferase, Aspartate Aminotransferase, creatinine and uric acid increased in tested periods.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Protective role of zeolites as mycotoxins binder in preventing the toxicological effects of Ochratoxin A on functional status of the mammalian liver and kidneys

  • 期刊论文

  • 发表日期：

    2025年8月7日

查看全文
  • Eman M. Abdelkareem,
  • Sulaiman A. Alsalamah,
  • Mohammed Ibrahim Alghonaim,
  • Tarek M. Abdelghany,
  • Medhat A. El-Naggar

摘要

Ochratoxin A (OTA), a secondary metabolic product, is one of the most vicious mycotoxins produced by a large species of filamentous fungi that are often associated with different grains and have tolerance against unfavorable conditions. It has a fatal effect on the health of mammals through its direct impact on the efficiency and functions of several body organs. In this study, 153 random assorted samples of barley, yellow corn, soybean, and wheat grains were collected from four different regions of Saudi Arabia. The highest OTA contamination in barley, yellow corn, soybean and wheat grains was 53.0, 210.6, 146.6, and 51.6 µg kg− 1, respectively. While, the highest average of OTA was recorded in yellow corn grains as 156.67 µg kg− 1 and the lowest as 13.3 µg kg− 1 in barley. Aspergillus ochraceus and A. carbonarius were identified as ochratoxigenic species by BIOLOG technique. The highest relative density (RD %) was recorded for A. ochraceus in yellow corn grains as 8.33% and decreased in barley, soybean and wheat as 5.56, 6.90, and 7.69%, respectively. Clinoptilolite binder reduced OTA concentration in all tested isolates but to varying rates, under recommended dose. The highest reduction was 26.6% with A. ochraceus, while reached 30% with A. carbonarius after 21 days. Mice were fed on yellow corn grains contaminated artificially by mild ochratoxigenic isolate (RIY-C1) resulted in increase of OTA to 5.65, 17.84 and 19.25 µg kg− 1 after 15, 30, and 45 days, respectively. In conjunction with OTA increasing in mice-feed, the activity of liver and kidney function as Alanine Aminotransferase, Aspartate Aminotransferase, creatinine and uric acid increased in tested periods.