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<p>Today, detoxification of mycotoxins has become a challenging issue because of their carcinogenicity, triggering of oxidative stress, and organ dysfunction. Studies have reported the reduction of mycotoxins by bacteria in absorption and degradation. There is a research gap in understanding the detoxification mechanism of mycotoxins by <i>Lactobacillus</i> species, and there is no coherent, precise, or accurate conclusion regarding this. The objective of this study was to conduct an extensive research and compare the mechanism of mycotoxin decontamination by Lactic Acid Bacteria (LAB), especially <i>Lactobacilli</i>, and non-lactic acid bacteria such as <i>Bacillus</i> spp. These findings indicate that <i>lactobacilli</i> can diminish mycotoxins mainly by binding to the cell wall, whereas other bacteria can do so only through enzymatic degradation. Oxidoreductase group enzymes are vital in transforming mycotoxins into safe or less toxic catabolites. Detoxification of mycotoxins by enzymes appears more practical and economical because of mycotoxins’ weak and unstable binding to the bacterial surface. This research provides insights into the practical isolation and use of appropriate bacteria or enzymes to detoxify specific mycotoxins or groups of mycotoxins for industrial applications.</p>

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Comparative investigation of Mycotoxin detoxification mechanisms by lactic acid bacteria (Lactobacillus species) and non-lactic acid bacteria

  • 期刊论文

  • 发表日期：

    2025年4月26日

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  • Milad Nabgan,
  • Nabi Shariatifar,
  • Tayebeh Zeinali

摘要

Today, detoxification of mycotoxins has become a challenging issue because of their carcinogenicity, triggering of oxidative stress, and organ dysfunction. Studies have reported the reduction of mycotoxins by bacteria in absorption and degradation. There is a research gap in understanding the detoxification mechanism of mycotoxins by Lactobacillus species, and there is no coherent, precise, or accurate conclusion regarding this. The objective of this study was to conduct an extensive research and compare the mechanism of mycotoxin decontamination by Lactic Acid Bacteria (LAB), especially Lactobacilli, and non-lactic acid bacteria such as Bacillus spp. These findings indicate that lactobacilli can diminish mycotoxins mainly by binding to the cell wall, whereas other bacteria can do so only through enzymatic degradation. Oxidoreductase group enzymes are vital in transforming mycotoxins into safe or less toxic catabolites. Detoxification of mycotoxins by enzymes appears more practical and economical because of mycotoxins’ weak and unstable binding to the bacterial surface. This research provides insights into the practical isolation and use of appropriate bacteria or enzymes to detoxify specific mycotoxins or groups of mycotoxins for industrial applications.