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Purpose <p>The cell culture technology for <i>Theileria annulata</i> schizont-infected cells plays a vital role in basic research and control of bovine theileriosis. <i>T. annulata</i> is an intracellular parasite transmitted by some species of ticks.</p> Methods <p>Unlike other Apicomplexa parasites, <i>T. annulata</i> can infect and transform host B cells, dendritic cells and macrophages, further induce the transformed cells yield some cancer-like phenotypes. The attenuated parasites were obtained through in vitro culture technology, which can effectively prevent <i>T. annulata</i> infection.</p> Results <p>The cell culture has evolved from initial adherent culture to rolling bottle culture and then to suspension culture at present. In addition, the suspension culture has also been upgraded from basic serum-containing culture to serum-free culture.</p> Conclusion <p>This paper highlights the past, present and perspective about the cell culture technology with <i>T. annulata</i> schizont-infected cells, which will strongly underpin application of <i>T. annulata</i> vaccines and control of the parasite in the future.</p>

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The Culture Technology for the Transforming Parasite-Theileria Annulata Schizont-Infected Cells: Past–Present–Perspective

  • 期刊论文

  • 发表日期：

    2025年11月14日

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  • Quanying Ma,
  • Yuan Han,
  • Yuqing Ma,
  • Xiaoqiang Wang,
  • Zhi Li

摘要

Purpose

The cell culture technology for Theileria annulata schizont-infected cells plays a vital role in basic research and control of bovine theileriosis. T. annulata is an intracellular parasite transmitted by some species of ticks.

Methods

Unlike other Apicomplexa parasites, T. annulata can infect and transform host B cells, dendritic cells and macrophages, further induce the transformed cells yield some cancer-like phenotypes. The attenuated parasites were obtained through in vitro culture technology, which can effectively prevent T. annulata infection.

Results

The cell culture has evolved from initial adherent culture to rolling bottle culture and then to suspension culture at present. In addition, the suspension culture has also been upgraded from basic serum-containing culture to serum-free culture.

Conclusion

This paper highlights the past, present and perspective about the cell culture technology with T. annulata schizont-infected cells, which will strongly underpin application of T. annulata vaccines and control of the parasite in the future.