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Purpose <p>Current treatments for toxoplasmosis are often limited. This study aimed to assess the therapeutic efficacy of <i>Allium sativum</i> (garlic) extract loaded onto Fe-MOFs in a murine model of chronic toxoplasmosis.</p> Methods <p>Sixty-five mice were assigned to seven groups. All groups, except the healthy control (GI), were infected with the <i>Toxoplasma gondii</i> ME49 strain. Treatments included Fe-MOFs (GIII), spiramycin (GIV), spiramycin@Fe-MOFs (GV), garlic extract (GVI), and garlic extract@Fe-MOFs (GVII). In vitro drug toxicity for garlic, Fe-MOFs, and garlic extract@Fe-MOFs were detected. Brain cysts counted, histopathological changes in various organs, and parasite DNA load (P29 gene) were assessed post-treatment using real-time PCR.</p> Results <p>Spiramycin@Fe-MOFs (GV) and garlic extract @Fe-MOFs (GVII) groups showed a significant reduction in brain cyst burden (39.63% and 59.45%, respectively), along with marked improvement in histopathological changes compared to the other treated infected groups.</p> Conclusion <p>These findings support garlic@Fe-MOFs as a potential treatment for toxoplasmosis, demonstrating enhanced efficacy, reduced toxicity, and improved histopathological outcomes.</p>

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Therapeutic Effect of Allium sativum (Garlic) Extract Using Nanotechnology on Murine Chronic Toxoplasmosis

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年11月14日

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  • Doaa Abdulfttah Ahmad Amer,
  • Fatma Mohamad El-Lessy,
  • Ashraf M. Barakat,
  • Rehab Mohamed El Shahat,
  • Sabry A. Sadek,
  • Reda M. Abdelhameed,
  • Mona Mohammed Elderbawy

摘要

Purpose

Current treatments for toxoplasmosis are often limited. This study aimed to assess the therapeutic efficacy of Allium sativum (garlic) extract loaded onto Fe-MOFs in a murine model of chronic toxoplasmosis.

Methods

Sixty-five mice were assigned to seven groups. All groups, except the healthy control (GI), were infected with the Toxoplasma gondii ME49 strain. Treatments included Fe-MOFs (GIII), spiramycin (GIV), spiramycin@Fe-MOFs (GV), garlic extract (GVI), and garlic extract@Fe-MOFs (GVII). In vitro drug toxicity for garlic, Fe-MOFs, and garlic extract@Fe-MOFs were detected. Brain cysts counted, histopathological changes in various organs, and parasite DNA load (P29 gene) were assessed post-treatment using real-time PCR.

Results

Spiramycin@Fe-MOFs (GV) and garlic extract @Fe-MOFs (GVII) groups showed a significant reduction in brain cyst burden (39.63% and 59.45%, respectively), along with marked improvement in histopathological changes compared to the other treated infected groups.

Conclusion

These findings support garlic@Fe-MOFs as a potential treatment for toxoplasmosis, demonstrating enhanced efficacy, reduced toxicity, and improved histopathological outcomes.