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Introduction <p>This study aimed to investigate the influence of benznidazole (BZN) origin on its in vitro potency against various <i>Trypanosoma cruzi</i> strains.</p> Methods <p>Pure BZN, purified BZN, and the pharmaceutical formulation Abarax were evaluated for their activity against several parasite strains.</p> Results <p>Results demonstrated significant variability in BZN’s effectiveness, contingent upon both its specific form and the <i>T. cruzi</i> strain under investigation. Half-maximal inhibitory concentrations (IC<sub>50</sub> values) exhibited a wide range, indicating that the potency of BZN is not uniform across all its forms or against all parasite strains.</p> Conclusion <p>In conclusion, this study elucidates the complex interaction between BZN and <i>T. cruzi</i>. The parasite’s response to BZN can vary even within a single strain, influenced by the drug’s specific presentation. These findings underscore the critical importance of considering both parasite diversity and drug formulation when assessing the efficacy of treatments in laboratory assays.</p>

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Analysis of the Behavior of Trypanosoma cruzi in Culture Against Different Dosage Forms of Benznidazole: Experimental Insights

  • 期刊论文

  • 发表日期：

    2025年9月3日

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  • Jaime López-Domínguez,
  • Aracely López-Monteon,
  • Paulina Ochoa-Martínez,
  • Josue Rafael González-García,
  • Rodolfo Peña-Rodríguez,
  • Etienne Waleckx,
  • Joel Moo-Millán,
  • Angel Ramos-Ligonio

摘要

Introduction

This study aimed to investigate the influence of benznidazole (BZN) origin on its in vitro potency against various Trypanosoma cruzi strains.

Methods

Pure BZN, purified BZN, and the pharmaceutical formulation Abarax were evaluated for their activity against several parasite strains.

Results

Results demonstrated significant variability in BZN’s effectiveness, contingent upon both its specific form and the T. cruzi strain under investigation. Half-maximal inhibitory concentrations (IC50 values) exhibited a wide range, indicating that the potency of BZN is not uniform across all its forms or against all parasite strains.

Conclusion

In conclusion, this study elucidates the complex interaction between BZN and T. cruzi. The parasite’s response to BZN can vary even within a single strain, influenced by the drug’s specific presentation. These findings underscore the critical importance of considering both parasite diversity and drug formulation when assessing the efficacy of treatments in laboratory assays.