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<p>Psychological pain serves as a robust predictor of suicide attempts (SAs) in patients with major depressive disorder (MDD). However, the neural characteristics of pain processing, independent of specific psychiatric diagnoses, and their relationships with SAs remain unclear. This study aimed to identify transdiagnostic and transparadigmatic neural correlates of pain processing in suicide attempters with mood disorders. Participants were categorized into groups and subgroups based on their suicide attempt histories, diagnostic category, and the task paradigms they completed. Representational similarity analyses were utilized both in regions of interest and through whole-brain searchlight analysis to explore psychological pain-induced neural patterns linked to SAs. Our findings demonstrate that, at the behavioral levels, pain avoidance is a significant transdiagnostic predictor of SAs across mood disorders. The MDD-SA group exhibited a transparadigmatic neural consistency in the left middle orbitofrontal cortex (OFC) and bilateral thalamus during punishment processing. Furthermore, a transdiagnostic SA-related activation pattern was identified in the right OFC, characterized by distinct spatial configurations rather than diffuse activity.</p>

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Activation in the right orbitofrontal cortex during pain processing as a transdiagnostic neural representation in suicide attempters

  • 期刊论文

  • 发表日期：

    2026年3月5日

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  • Haobing Wei,
  • Huanhuan Li,
  • Ziyu Hao,
  • Yuying Chen,
  • Jiahe Chen,
  • Youwei Fu

摘要

Psychological pain serves as a robust predictor of suicide attempts (SAs) in patients with major depressive disorder (MDD). However, the neural characteristics of pain processing, independent of specific psychiatric diagnoses, and their relationships with SAs remain unclear. This study aimed to identify transdiagnostic and transparadigmatic neural correlates of pain processing in suicide attempters with mood disorders. Participants were categorized into groups and subgroups based on their suicide attempt histories, diagnostic category, and the task paradigms they completed. Representational similarity analyses were utilized both in regions of interest and through whole-brain searchlight analysis to explore psychological pain-induced neural patterns linked to SAs. Our findings demonstrate that, at the behavioral levels, pain avoidance is a significant transdiagnostic predictor of SAs across mood disorders. The MDD-SA group exhibited a transparadigmatic neural consistency in the left middle orbitofrontal cortex (OFC) and bilateral thalamus during punishment processing. Furthermore, a transdiagnostic SA-related activation pattern was identified in the right OFC, characterized by distinct spatial configurations rather than diffuse activity.