Scholarlink

Purpose <p>Pseudocontinuous arterial spin labeling (PCASL) is an innovative technique for measuring cerebral blood flow (CBF). The aim of this study was to investigate alterations in CBF and connectivity in anti-leucine-rich glioma-inactivated 1 autoimmune encephalitis (anti-LGI1-AE).</p> Methods <p>CBF was analyzed in 27 acute anti-LGI1-AE patients and 81 healthy controls using arterial spin labeling. Regions with altered CBF were designated as regions of interest (ROIs)<b>，</b>followed by between-group CBF connectivity comparisons.</p> Results <p>Patients exhibited increased CBF in the bilateral putamen, bilateral amygdala (Amygdala_Bi), bilateral hippocampus (Hippocampus_Bi), bilateral parahippocampus, and right insula (Insula_R) (<i>P</i> = 0.001, cluster-level familywise error [FWE] corrected). The following regions showed decreased CBF connectivity (<i>P</i> &lt; 0.05, FWE-corrected): the right hippocampus demonstrated decreased connectivity with the right superior temporal gyrus (STG_R), right Rolandic operculum (RO_R), right caudate nucleus (Caudate_R), right superior temporal pole (STP_R), right middle cingulate gyrus (MCG_R), and right anterior cingulate gyrus; the right amygdala displayed decreased connectivity with the STG_R, RO_R, STP_R, right putamen, Caudate_R, MCG_R, and right supplementary motor area; the Insula_R exhibited reduced connectivity with the right middle temporal gyrus and STG_R; the right parahippocampal gyrus presented weakened connectivity with the STP_R, RO_R, Insula_R, MCG_R, and left MTG; the left hippocampus showed decreased connectivity with the left STG and insula; the left parahippocampal gyrus manifested impaired connectivity with the left lingual gyrus and left precuneus. Increased CBF connectivity was observed between Amygdala_Bi and Hippocampus_Bi (<i>P</i> = 0.001, FWE-corrected).</p> Conclusion <p>PCASL imaging revealed increased CBF in subcortical regions and widespread disruption of CBF connectivity in patients with anti-LGI1 AE, which may offer valuable insights into the neural mechanisms underlying the clinical manifestations of this condition.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Acute cerebral blood flow and its connectivity in patients with anti-LGI1 autoimmune encephalitis: an arterial spin labeling study

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年3月19日

查看全文
  • Ping Jiang,
  • Lei Wang,
  • Dingfeng Sun,
  • Ailiang Miao,
  • Xiaoshan Wang

摘要

Purpose

Pseudocontinuous arterial spin labeling (PCASL) is an innovative technique for measuring cerebral blood flow (CBF). The aim of this study was to investigate alterations in CBF and connectivity in anti-leucine-rich glioma-inactivated 1 autoimmune encephalitis (anti-LGI1-AE).

Methods

CBF was analyzed in 27 acute anti-LGI1-AE patients and 81 healthy controls using arterial spin labeling. Regions with altered CBF were designated as regions of interest (ROIs)，followed by between-group CBF connectivity comparisons.

Results

Patients exhibited increased CBF in the bilateral putamen, bilateral amygdala (Amygdala_Bi), bilateral hippocampus (Hippocampus_Bi), bilateral parahippocampus, and right insula (Insula_R) (P = 0.001, cluster-level familywise error [FWE] corrected). The following regions showed decreased CBF connectivity (P < 0.05, FWE-corrected): the right hippocampus demonstrated decreased connectivity with the right superior temporal gyrus (STG_R), right Rolandic operculum (RO_R), right caudate nucleus (Caudate_R), right superior temporal pole (STP_R), right middle cingulate gyrus (MCG_R), and right anterior cingulate gyrus; the right amygdala displayed decreased connectivity with the STG_R, RO_R, STP_R, right putamen, Caudate_R, MCG_R, and right supplementary motor area; the Insula_R exhibited reduced connectivity with the right middle temporal gyrus and STG_R; the right parahippocampal gyrus presented weakened connectivity with the STP_R, RO_R, Insula_R, MCG_R, and left MTG; the left hippocampus showed decreased connectivity with the left STG and insula; the left parahippocampal gyrus manifested impaired connectivity with the left lingual gyrus and left precuneus. Increased CBF connectivity was observed between Amygdala_Bi and Hippocampus_Bi (P = 0.001, FWE-corrected).

Conclusion

PCASL imaging revealed increased CBF in subcortical regions and widespread disruption of CBF connectivity in patients with anti-LGI1 AE, which may offer valuable insights into the neural mechanisms underlying the clinical manifestations of this condition.