Abstract <p>Zinc-based alloys have emerged as promising biodegradable metals, yet their inadequate mechanical strength significantly restricts their clinical applications. To address this limitation, multi-pass equal channel angular pressing (ECAP) was employed to process a Zn-0.8Mn alloy, providing a platform to systematically investigate the regulation mechanisms governing its microstructural evolution, mechanical performance, and corrosion behavior. The as-cast alloy initially consists of a Zn matrix and Zn/MnZn₁₃ eutectic phases. While multi-pass ECAP (2–8 passes) preserves the fundamental phase constitution, it induces significant grain refinement, dynamic precipitation of MnZn₁₃ at grain boundaries, and enhanced microstructural homogeneity. Mechanical testing reveals a simultaneous enhancement in both strength and ductility; specifically, after 8 passes, the tensile yield strength (TYS) and elongation (EL) reach 208.7 ± 1.5&#xa0;MPa and 32.3 ± 4.4%, respectively. Concurrently, the corrosion resistance is improved with increasing ECAP passes, with the corrosion rate decreasing to 0.0233&#xa0;mm/y after 8 passes. These findings suggest that the Zn-0.8Mn alloy is a promising candidate for biodegradable applications, and the ECAP process provides an effective route for the concurrent optimization of mechanical properties and degradation rates.</p> Graphical Abstract <p></p>