<p>Peri-implant infections represent a primary cause of titanium implant failure. The development of surface functional coatings that combine highly effective antibacterial properties and superior osteogenic activity is crucial in addressing this challenge. In this study, a periodic micro-nano array with a spacing of 0.175&#xa0;mm has been fabricated on medical-grade titanium <i>via</i> laser etching. A composite coating of titanium dioxide (TiO₂) nanorods decorated with silver (Ag) and zinc (Zn) nanoparticles was produced using a combination of hydrothermal synthesis, UV reduction, and spin coating with subsequent annealing. This coating demonstrates an enhanced comprehensive performance, delivering 91.49 and 94.05% antibacterial inhibition with respect to <i>Escherichia coli</i> and <i>Staphylococcus aureus</i>, respectively. The sample exhibited a high degree of biocompatibility during initial cell culture. The improved performance is attributed to a synergistic antibacterial effect of Ag⁺ and Zn²⁺ ions coupled with the surface micro-nanostructure. The proposed synthetic approach achieves a balance of potent antibacterial activity and osteogenic activity while significantly reducing Ag usage. The findings of this study establish an effective strategy for developing low-toxicity, long-lasting dual-functional coatings for titanium implants.</p> Graphical Abstract <p></p>