<p>Ti-6.5Al-3.5Mo-1.5Zr-0.3Si (TC11) is a typical <i>α</i> + <i>β</i> titanium alloy that is promising in aerospace and marine fields due to its outstanding performance. In practical applications, it has been found that the surface properties of TC11 alloy exhibit mechanical anisotropy on different surfaces. To explore the anisotropy mechanism of TC11 alloy in various application backgrounds, an alloy with dimensions of 85 × 70 × 12&#xa0;mm³ was clad using laser melting deposition technology. Its microstructure, microhardness, friction, and electrochemical corrosion resistance on different surfaces were then analyzed. The results show that the alloy phase mainly consists of <i>α</i>-Ti and a small amount of <i>β</i>-Ti, and there exist differences in the dendrite growth mechanisms among the three surfaces. Among them, the acicular <i>α</i>′ martensite with distinct primary and secondary orientations on the XZ surface effectively impedes dislocation motion, resulting in higher hardness and superior wear resistance. The average microhardness of the XZ surface is about 1.03 times and 1.15 times higher than that of the XY and YZ surfaces. The wear rate of the XZ surface is 91% and 85% of the XY and YZ surfaces, respectively. Meanwhile, the dense and irregular dendrites on the XY surface determine a denser oxide film, thus exhibiting the best electrochemical corrosion resistance.</p>