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<p>Recapitulating the in vivo microenvironments of damaged tissues through modulation of the physicochemical properties of scaffolds can enhance cell proliferation and differentiation. However, it is often a technical challenge to fully mimic the hierarchical structure of the target tissues. Inspired by hierarchical natural bone, we developed, for the first time, tricalcium phosphate scaffolds with four-level hierarchical structures (FH-TCP) across macro- to nanoscales, via freeze casting combined with material jetting templating. The mechanical property of the FH-TCP scaffolds can be tailored to be close to the cancellous bone (0.5 ~ 3.5&#xa0;MPa). In addition, the better cell viability of FH-TCP demonstrates great potential for practical applications.</p>

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Bioinspired Hierarchical Porous Tricalcium Phosphate Scaffold Prepared via Freeze Casting Combined with Material Jetting Templating

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年8月18日

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  • Jingyu Liu,
  • Sepanta Hosseinpour,
  • Chun Xu,
  • Tony Wang,
  • Cheng Yan

摘要

Recapitulating the in vivo microenvironments of damaged tissues through modulation of the physicochemical properties of scaffolds can enhance cell proliferation and differentiation. However, it is often a technical challenge to fully mimic the hierarchical structure of the target tissues. Inspired by hierarchical natural bone, we developed, for the first time, tricalcium phosphate scaffolds with four-level hierarchical structures (FH-TCP) across macro- to nanoscales, via freeze casting combined with material jetting templating. The mechanical property of the FH-TCP scaffolds can be tailored to be close to the cancellous bone (0.5 ~ 3.5 MPa). In addition, the better cell viability of FH-TCP demonstrates great potential for practical applications.