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<p>In this work, CoFe<sub>2</sub>O<sub>4</sub>/MnFe<sub>2</sub>O<sub>4</sub> core/shell nanostructures were fabricated using the thermal decomposition method. CoFe<sub>2</sub>O<sub>4</sub> (CFO) nanoparticles with an average size of about 10&#xa0;nm were used as seeds for the growth of MnFe<sub>2</sub>O<sub>4</sub> particles. X-ray diffraction (XRD) analysis results showed that the fabricated core/shell samples have a single-phase face-centered cubic spinel structure similar to the CoFe<sub>2</sub>O<sub>4</sub> sample but with a larger crystal size. Moreover, transmission electron microscopy (TEM) observations showed that the size of nanoparticles of the core/shell samples increased by 1.0–3.5&#xa0;nm with respect to that of the CoFe<sub>2</sub>O<sub>4</sub> sample, indicating the formation of the MnFe<sub>2</sub>O<sub>4</sub> shell layer. The magnetic measurement results showed that a thin MnFe<sub>2</sub>O<sub>4</sub> shell existed in the core/shell samples resulting in an increased saturation magnetization (<i>M</i><sub>s</sub>) and a slight decrease in coercivity (<i>H</i><sub>c</sub>) compared to the CFO core sample. In contrast, a thicker shell layer resulted in decreased <i>M</i><sub>s</sub> and <i>H</i><sub>c</sub> values compared to the CFO core sample. The magnetic hysteresis curve measured at a low temperature and high magnetic field showed the difference between the reference mixed sample and the core/shell nanostructured sample. Dynamic light scattering (DLS) analysis showed that the liquid samples had uniform particle sizes and high stability. The liquid samples were tested for toxicity on Hep-G2 cancer cell lines and showed no toxicity on this cell line. The core/shell structured samples exhibited higher specific absorption rate (SAR) values than the individual core sample. Notably, the sample with the thickest shell achieved a SAR of 246.62&#xa0;W/g, while the relaxation rate (<i>r</i><sub>2</sub>) of the sample with the thinnest shell was 43.71 (mM&#xa0;s)<sup>−1</sup>. These initial results suggest our fabricated CoFe<sub>2</sub>O<sub>4</sub>/MnFe<sub>2</sub>O<sub>4</sub> core/shell nanostructures exhibit potential biomedical applications, especially in magnetic hyperthermia treatment and magnetic resonance imaging (MRI) contrast enhancement.</p> Graphical Abstract <p></p>

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Enhanced Magnetic Hyperthermia and MRI Performance of CoFe2O4/MnFe2O4 Core/Shell Nanostructures

  • 期刊论文

  • 发表日期：

    2025年1月3日

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  • V. T. K. Oanh,
  • L. T. H. Phong,
  • N. H. A. Thu,
  • N. X. Truong,
  • P. H. Nam,
  • N. N. P. Vy,
  • N. T. Luyen,
  • V. T. B. Ngoc

摘要

In this work, CoFe2O4/MnFe2O4 core/shell nanostructures were fabricated using the thermal decomposition method. CoFe2O4 (CFO) nanoparticles with an average size of about 10 nm were used as seeds for the growth of MnFe2O4 particles. X-ray diffraction (XRD) analysis results showed that the fabricated core/shell samples have a single-phase face-centered cubic spinel structure similar to the CoFe2O4 sample but with a larger crystal size. Moreover, transmission electron microscopy (TEM) observations showed that the size of nanoparticles of the core/shell samples increased by 1.0–3.5 nm with respect to that of the CoFe2O4 sample, indicating the formation of the MnFe2O4 shell layer. The magnetic measurement results showed that a thin MnFe2O4 shell existed in the core/shell samples resulting in an increased saturation magnetization (Ms) and a slight decrease in coercivity (Hc) compared to the CFO core sample. In contrast, a thicker shell layer resulted in decreased Ms and Hc values compared to the CFO core sample. The magnetic hysteresis curve measured at a low temperature and high magnetic field showed the difference between the reference mixed sample and the core/shell nanostructured sample. Dynamic light scattering (DLS) analysis showed that the liquid samples had uniform particle sizes and high stability. The liquid samples were tested for toxicity on Hep-G2 cancer cell lines and showed no toxicity on this cell line. The core/shell structured samples exhibited higher specific absorption rate (SAR) values than the individual core sample. Notably, the sample with the thickest shell achieved a SAR of 246.62 W/g, while the relaxation rate (r2) of the sample with the thinnest shell was 43.71 (mM s)−1. These initial results suggest our fabricated CoFe2O4/MnFe2O4 core/shell nanostructures exhibit potential biomedical applications, especially in magnetic hyperthermia treatment and magnetic resonance imaging (MRI) contrast enhancement.

Graphical Abstract