<p>This study investigates the impact of multi-walled carbon nanotubes (MWCNTs) and tin dioxide nanoparticles (SnO₂) additions on porous Ti_43.93-Ni_56.07 shape memory alloys (SMAs) tribological behavior. Porous Ti-Ni SMAs are increasingly favored for biomedical applications due to their low modulus and improved osseointegration capabilities. Adding MWCNTs and SnO₂ is explored to enhance these alloys’ wear resistance and antibacterial properties. The experimental setup involves varying the weight percentages of MWCNTs (x = 0, 0.5, 0.75, and 1) wt.pct and SnO₂ (y = 0, 0.5, 1, and 1.5) wt.pct in the Ti_43.93-Ni_56.07-x-y matrix. The samples were subjected to tribological testing under different loads of (0.5 and 1) kg and (10 and 20) hertz speeds, and the corresponding wear loss, wear diameter, and wear depth were measured. Statistical analyses, including one-factor ANOVA, two-way ANOM, and regression tests, were performed to determine the significance of the results. The findings reveal that the combination of 0.5 wt.pct MWCNTs and 0.5 wt.pct SnO₂ significantly reduces wear loss and wear diameter, highlighting the synergistic effect of these additives. Additionally, biocompatibility tests demonstrated improved antibacterial properties with increased MWCNTs and SnO₂ concentrations, especially at 1 wt.pct each. These results suggest that optimizing the concentrations of MWCNTs and SnO₂ in Ti-Ni SMAs can significantly enhance their tribological and antibacterial performance, making them suitable for biomedical applications.</p>