This study explores the combined effects of strain-rate and temperature on the compressive behavior and microstructural evolution of Ti–15Mo (wt pct) over a temperature range of \(25\,^{\circ }\) C to \(450\,^{\circ }\) C and strain-rates from \(1.1 \times 10^{-3}\) to \(3.2\times 10^{3}\,{\hbox {s}}^{-1}\) using a high-temperature Kolsky system. The results show that yield strength (YS) increases with strain-rate but generally decreases with temperature. Work hardening rate (WHR) is higher under quasi-static loading, with dynamic Hall–Petch effect driven by 332 \(\langle 113 \rangle \) twin formation at low temperatures. As temperature rises, dislocation recovery suppresses this effect, leading to a decrease in WHR. At \(450\,^{\circ }\) C under quasi-static loading, \(\omega \) precipitate strengthening causes an increase in both YS and WHR. These differences are influenced by a shift in the dominant deformation mechanism, which is affected by both temperature and strain-rate. Twinning dominates at high strain-rates across all temperatures, but the amount of twinning decreases with increasing temperature. In contrast, under quasi-static loading, the primary mechanism shifts from twinning to slip as temperature increases. The capacity for energy absorption is greater under high rate loading up to \(450\,^{\circ }\) C, at which point precipitate strengthening increases WHR under quasi-static loading.