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Background <p>The introduction of interdisciplinary and targeted treatment approaches has significantly improved the overall survival of patients with metastatic colorectal cancer (mCRC). This article presents the various options for interventional and systemic sequential therapy.</p> Methods <p>A descriptive summary of current studies is provided based on literature research in PubMed as well as on guidelines and congress contributions from the European Society of Medical Oncology and the American Society of Clinical Oncology.</p> Results <p>Resection and/or local ablative procedures achieve a&#xa0;5-year survival rate of up to 45% and are potentially curative. The value of liver transplantation is still unclear. Based on the molecular biology of the tumor, first-line systemic therapy is also increasingly targeted.</p> Conclusion <p>The use of targeted and interventional treatment strategies, particularly in the case of objective response, should always be considered to optimize prognosis and outcome.</p>

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Sequenztherapie des metastasierten kolorektalen Karzinoms

  • 期刊论文

  • 发表日期：

    2025年10月21日

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  • Arndt Stahler,
  • Wenzel Schöning,
  • Philipp Haber,
  • Bernhard Gebauer

摘要

Background

The introduction of interdisciplinary and targeted treatment approaches has significantly improved the overall survival of patients with metastatic colorectal cancer (mCRC). This article presents the various options for interventional and systemic sequential therapy.

Methods

A descriptive summary of current studies is provided based on literature research in PubMed as well as on guidelines and congress contributions from the European Society of Medical Oncology and the American Society of Clinical Oncology.

Results

Resection and/or local ablative procedures achieve a 5-year survival rate of up to 45% and are potentially curative. The value of liver transplantation is still unclear. Based on the molecular biology of the tumor, first-line systemic therapy is also increasingly targeted.

Conclusion

The use of targeted and interventional treatment strategies, particularly in the case of objective response, should always be considered to optimize prognosis and outcome.