<p>The autoignition process of methanol/n-heptane dual-fuel (DF) premixtures is studied in a simplified inflow-outflow configuration using numerical simulations under engine-like conditions. Variations in the initial gas temperatures, inlet velocities, and methanol substitution ratio (MSR) on the low-temperature combustion (LTC) and high-temperature combustion (HTC) of DF mixtures are investigated. The LTC is initiated at the locations close to the inlet. A propagating hot flame front is observed after the formation of the HTC. Both the LTC and HTC are delayed at a high value of the MSR. The negative temperature coefficients (NTC) characteristics are insignificant when the MSR reaches 54% due to the decreased LTC at a low concentration of n-heptane. The ignition delay times (IDTs) for the DF mixtures are prolonged with the increase in the MSR due to the competition of OH between n-heptane and methanol. OH is consumed by the reaction pathway CH₃OH+OH=CH₂OH+H₂O, which inhibits the autoignition of fuel/air mixtures and delays the second-stage ignition of n-heptane. Meanwhile, the longer residence time causes a longer distance between the HTC region and the inlet. Finally, the ignition Damköhler number (<i>Da</i>_ign) defined as the ratio of the residence time to the IDT is introduced to reveal the stabilization process of the DF mixtures. The values of the <i>Da</i>_ign are all lower than unity at different inlet velocities and MSR, indicating that diffusion plays a critical role for LTC. However, larger values of <i>Da</i>_ign are observed for the HTC indicating that autoignition dominates the oxidization process.</p>