<p>This paper presents a preliminary modeling investigation into the inhibiting effect of the internal walls of micro-scale combustor on the auto-ignition characteristics of n-butane/air mixtures. Key gas-phase species for surface model were selected based on reaction temperature ranges and incorporated into a skeletal n-butane oxidation mechanism. Simulations were performed in a closed adiabatic environment to evaluate the impact of surface reactions on ignition delay times under varying operation conditions, including initial gas-phase temperature, pressure, equivalence ratio, surface-to-volume ratio, and wall adsorption coefficient. Experimental comparisons indicated longer measured ignition delay times than predicated values in medium and low temperature ranges due to surface chemical effects, with up to 35.42% deviation. Simulation results highlighted the importance of PC₄H₉O₂ and SC₄H₉O₂ radicals’ wall reaction at 700–800 K, increasing ignition delay times by 10⁴ to 10⁵ times. High-temperature and low-pressure conditions intensified this inhibitory effect. Increased wall adsorption coefficient significantly extended ignition delays, particularly under lean-fuel condition. Higher surface-to-volume ratio led to the greater consumption of gas-phase radical through heterogeneous surface combination. Beyond a certain threshold, the ignition delay time increase rate slowed down and tended to stabilize. Sensitivity analysis revealed that CH₃+HO₂→CH₃O+OH was critical for high-temperature auto-ignition, while surface reactions became less sensitive with increasing equivalence ratio. This work provides a foundation for future modeling efforts that aim to couple reaction kinetics with a detailed physical model for micro-scale combustion applications of n-butane.</p>