<p>Micropropagation is one of the most common applications of plant tissue culture. This technique enhances genetic improvement programs by producing plants of high genetic and phytosanitary quality. However, despite its advantages and benefits, the commercial scaling of this <i>in vitro</i> propagation technique has been limited due to the use of conventional <i>in vitro</i> culture systems on semi-solid media. As an alternative, using liquid media in temporary immersion systems represents a way to increase biological yield and achieve semi-automation during micropropagation. This article follows a systematic literature review approach and discusses the most important factors for the commercial scaling of micropropagation using temporary immersion systems, including time and immersion frequency, volume of culture medium, explant density per bioreactor, proliferation time, and number of subcultures. In plants, hormesis or hormetic effect is the stimulation of development at a low dose and/or concentration of a stressor, whereas there is an inhibition of development or death at a high dose and/or concentration of the stressor. Additionally, this review compares different bioreactors and the use of hormetic compounds as optimization alternatives in micropropagation protocols. The short-term operability and biomass production make temporary immersion systems innovative alternatives for the commercial micropropagation of plants. In conclusion, temporary immersion systems contribute to the large-scale production of plants <i>via</i> micropropagation; however, micropropagation scaling-up is not easy. It requires extensive research and standardization to obtain an efficient and reproducible micropropagation protocol successfully.</p>