<p>Africa, with 55 Member States and over 1 billion people, is projected to nearly double its population to 2.5&#xa0;billion by 2050, presenting both opportunities and challenges for sustainable development. Agriculture employs 65% of the labour force and contributes 32% to gross domestic product. The aim of this perspective is to highlight the challenges and opportunities of achieving net-zero agriculture in Africa while proffering appropriate recommendations. The primary issues are how extreme weather events affect food security and how to cut emissions from livestock farming as well as rice cultivation and fertilizer usage alongside evaluating current policies that support climate-smart agricultural practices. Africa needs to investigate how its expanding young population along with research and innovation can advance the move towards net-zero agricultural practices. Challenges of insufficient data availability together with ineffective policy enforcement, financial barriers, and limited awareness, decreasing precipitation levels coupled with regional conflicts and population migration hinder progress in achieving net-zero agriculture on the continent. However, Africa possesses substantial opportunities through its extensive arable land combined with its youthful workforce and renewable energy capabilities. Africa needs to obtain climate funds and strengthen regional partnerships while enhancing climate information services and creating inclusive and gender-responsive policies to address these issues. Investing in innovative technologies alongside renewable energy sources and crops resistant to climate change stands as an essential strategy. The implementation of early warning systems along with the development of alternative livelihoods will enhance efforts towards sustainable management of climate-induced migration. Africa will develop a climate-resilient agricultural system by confronting existing challenges while capitalizing on emerging opportunities.</p>