<p>Recent emphasis on transdisciplinary teams in science offers an opportunity for biostatisticians to assume roles beyond data management and analysis. Biostatisticians contribute to all phases of research, from hypothesis formulation and rigorous study design to data analysis and interpretation. Yet, their contributions are often underrecognized. We argue for better integration of biostatisticians in research training and team structures. Postgraduate physician-scientist training should include mentorship from biostatisticians and education on collaborative skills. Fully integrating biostatisticians as co-investigators improves rigor, reproducibility, and innovation. Institutional support, including protected time and updated promotion criteria, is essential to support sustained collaboration. Structural changes must address limited access to biostatistical resources, especially in institutions lacking Clinical and Translational Science Awards. Clarifying roles and responsibilities at the outset, including through tools like team charters, facilitates alignment and prevents conflict. Elevating biostatisticians as scientific partners strengthens team dynamics and improves research quality. Team-based biomedical research—when genuinely collaborative—synergistically advances both methodological rigor and health outcomes. This perspective is especially relevant for general internists engaged in increasingly complex, transdisciplinary research. The future of health science innovation will depend on dismantling traditional silos and promoting meaningful, equitable scientific partnerships across disciplines.</p>