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Purpose <p>Detecting small pancreatic ductal adenocarcinomas (PDAC) is challenging owing to their difficulty in being identified as distinct tumor masses. This study assesses the diagnostic performance of a three-dimensional convolutional neural network for the automatic detection of small PDAC using both automatic tumor mass detection and indirect indicator evaluation.</p> Materials and methods <p>High-resolution contrast-enhanced computed tomography (CT) scans from 181 patients diagnosed with PDAC (diameter ≤ 2&#xa0;cm) between January 2018 and December 2023 were analyzed. The D/P ratio, which is the cross-sectional area of the MPD to that of the pancreatic parenchyma, was identified as an indirect indicator. A total of 204 patient data sets including 104 normal controls were analyzed for automatic tumor mass detection and D/P ratio evaluation. The sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) were evaluated to detect tumor mass. The sensitivity of PDAC detection was compared with that of the software and radiologists, and tumor localization accuracy was validated against endoscopic ultrasonography (EUS) findings.</p> Results <p>The sensitivity, specificity, PPV, and NPV for tumor mass detection were 77.0%, 76.0%, 75.5%, and 77.5%, respectively; for D/P ratio detection, 87.0%, 94.2%, 93.5%, and 88.3%, respectively; and for combined tumor mass and D/P ratio detections, 96.0%, 70.2%, 75.6%, and 94.8%, respectively. No significant difference was observed between the software’s sensitivity and that of the radiologist’s report (software, 96.0%; radiologist, 96.0%; <i>p</i> = 1). The concordance rate between software findings and EUS was 96.0%.</p> Conclusions <p>Combining indirect indicator evaluation with tumor mass detection may improve small PDAC detection accuracy.</p>

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Deep learning-based automatic detection of pancreatic ductal adenocarcinoma ≤ 2 cm with high-resolution computed tomography: impact of the combination of tumor mass detection and indirect indicator evaluation

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年7月18日

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  • Mizuki Ozawa,
  • Miyuki Sone,
  • Susumu Hijioka,
  • Hidenobu Hara,
  • Yusuke Wakatsuki,
  • Toshihiro Ishihara,
  • Chihiro Hattori,
  • Ryo Hirano,
  • Shintaro Ambo,
  • Minoru Esaki,
  • Masahiko Kusumoto,
  • Yoshiyuki Matsui

摘要

Purpose

Detecting small pancreatic ductal adenocarcinomas (PDAC) is challenging owing to their difficulty in being identified as distinct tumor masses. This study assesses the diagnostic performance of a three-dimensional convolutional neural network for the automatic detection of small PDAC using both automatic tumor mass detection and indirect indicator evaluation.

Materials and methods

High-resolution contrast-enhanced computed tomography (CT) scans from 181 patients diagnosed with PDAC (diameter ≤ 2 cm) between January 2018 and December 2023 were analyzed. The D/P ratio, which is the cross-sectional area of the MPD to that of the pancreatic parenchyma, was identified as an indirect indicator. A total of 204 patient data sets including 104 normal controls were analyzed for automatic tumor mass detection and D/P ratio evaluation. The sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) were evaluated to detect tumor mass. The sensitivity of PDAC detection was compared with that of the software and radiologists, and tumor localization accuracy was validated against endoscopic ultrasonography (EUS) findings.

Results

The sensitivity, specificity, PPV, and NPV for tumor mass detection were 77.0%, 76.0%, 75.5%, and 77.5%, respectively; for D/P ratio detection, 87.0%, 94.2%, 93.5%, and 88.3%, respectively; and for combined tumor mass and D/P ratio detections, 96.0%, 70.2%, 75.6%, and 94.8%, respectively. No significant difference was observed between the software’s sensitivity and that of the radiologist’s report (software, 96.0%; radiologist, 96.0%; p = 1). The concordance rate between software findings and EUS was 96.0%.

Conclusions

Combining indirect indicator evaluation with tumor mass detection may improve small PDAC detection accuracy.