Let \(\mathcal {A}\) be a \(*\) -algebra. For any \(\mathcal {A}, \mathscr {B}\in \mathcal {A}\) , the products \( \mathscr {A} \bullet \mathscr {B}=\mathscr {A}\mathscr {B}^*+\mathscr {B}\mathscr {A}^*\) , \([\mathscr {A}, \mathscr {B}]_*=\mathscr {A}\mathscr {B}^*-\mathscr {B}\mathscr {A}^*\) are called a bi-skew Jordan and bi-skew Lie product, respectively. In this paper, it is shown that every non-additive mixed bi-skew Jordan and bi-skew Lie triple derivation \(\Lambda : \mathcal {A}\rightarrow \mathcal {A}\) is an additive \(*\) -derivation.