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<p>Lactic acid (LA) is produced in the human body during the anaerobic breakdown of carbohydrates. Abnormally high concentrations of LA indicate lower levels of oxygen in the blood, that could result in heart failure, renal failure, lung diseases etc. Detecting LA could thus serve as a prognostic tool and so here we have fabricated an electrochemical sensor for detection of LA. Posnjakite Nanostructures (PN) were used in modifying a paraffin impregnated graphite electrode surface (PIGE/PN) which was then employed as the electrochemical sensor for LA. Fourier Transform Infrared Spectroscopy, X-ray Diffraction Spectroscopy, X-ray Photoelectron Spectroscopy, and Field Emission Scanning Electron Microscopy have been used to characterize the nanostructures. The electrochemical sensing of LA was carried out using square wave voltammetry (SWV) and Chronoamperometry (CA) showing the electrocatalytic nature of PN in LA oxidation. Using SWV, the PIGE/PN sensor showed linearity in the lower concentration range of 30 µM − 330 µM and higher concentration range of 0.03 mM – 7.4 mM with a limit of detection of 10 µM and a quantification limit of 33.3 µM. Using CA, the sensor showed linearity in the lower concentration range of 16.7 µM − 216 µM and higher concentration range of 10 mM − 90 mM with a limit of detection of 5.56 µM and a quantification limit of 18.58 µM. Selectivity of the sensor for LA was studied amperometrically in the presence of potent interferents. The stability and reproducibility of the enzymeless sensor have been thoroughly investigated, and its performance has been ascertained using real samples.</p>

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A copper based electrode as ultrasensitive nonenzymatic sensor for lactic acid detection

  • 期刊论文

  • 发表日期：

    2026年4月11日

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  • Sarah Jasmine Theresa T,
  • P. N. Deepa

摘要

Lactic acid (LA) is produced in the human body during the anaerobic breakdown of carbohydrates. Abnormally high concentrations of LA indicate lower levels of oxygen in the blood, that could result in heart failure, renal failure, lung diseases etc. Detecting LA could thus serve as a prognostic tool and so here we have fabricated an electrochemical sensor for detection of LA. Posnjakite Nanostructures (PN) were used in modifying a paraffin impregnated graphite electrode surface (PIGE/PN) which was then employed as the electrochemical sensor for LA. Fourier Transform Infrared Spectroscopy, X-ray Diffraction Spectroscopy, X-ray Photoelectron Spectroscopy, and Field Emission Scanning Electron Microscopy have been used to characterize the nanostructures. The electrochemical sensing of LA was carried out using square wave voltammetry (SWV) and Chronoamperometry (CA) showing the electrocatalytic nature of PN in LA oxidation. Using SWV, the PIGE/PN sensor showed linearity in the lower concentration range of 30 µM − 330 µM and higher concentration range of 0.03 mM – 7.4 mM with a limit of detection of 10 µM and a quantification limit of 33.3 µM. Using CA, the sensor showed linearity in the lower concentration range of 16.7 µM − 216 µM and higher concentration range of 10 mM − 90 mM with a limit of detection of 5.56 µM and a quantification limit of 18.58 µM. Selectivity of the sensor for LA was studied amperometrically in the presence of potent interferents. The stability and reproducibility of the enzymeless sensor have been thoroughly investigated, and its performance has been ascertained using real samples.