In this paper, we introduce the class of n-quasi skew [m, C]-symmetric operator on a Hilbert space which is a generalization of skew [m, C] -symmetric operators presented by M. Chō, B. Načevska-Nastovska, and J. Tomiyama. [On skew [m, C]-symmetric operators. Adv. Oper.Theory 2(4), 468–474 (2017)]. An operator T \(\in \) \({\mathscr {B}}({\mathscr {H}})\) is said to be n-quasi skew [m, C]-symmetric if \(\begin{aligned} T^{*n}\left( \underset{j=0}{\overset{m}{\sum }}\left( {\begin{array}{c}m\\ j\end{array}}\right) CT^{m-j}CT^{j}\right) T^{n}=0 \end{aligned}\) for some positive integers n and m. Some basic structural properties of this class are established with the help of operator matrix representation. In particular, we study the perturbation of an n-quasi skew [m, C]-symmetric operator with a nilpotent op- erator. Moreover, if T and S are doubly commuting such that T is \(n_{1}\) -quasi skew [m, C]-symmetric symmetric and S is \(n_{2}\) -quasi- \(\left[ k,C\right] \) -symmetric operator, then TS is an \(n_{3}=\) max \(\left\{ n_{1},n_{2}\right\} \) -quasi skew \(\left[ m+k-1,C \right] \) -symmetric operator under suitable conditions.