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<p>Autosomal dominant polycystic kidney disease (ADPKD) is the most frequent genetic kidney disorder. In addition to the loss of kidney function caused by the continuous growth of cysts, numerous extrarenal manifestations are possible. These can include cysts in the liver or pancreas, cerebral aneurysms and valvular heart diseases. There is often uncertainty regarding which diagnostic tests are necessary for patients with suspected ADPKD and which follow-up measures and specific treatment recommendations should be followed once the diagnosis is confirmed. The Kidney Disease: Improving Global Outcomes (KDIGO) guidelines on ADPKD, published in 2025, provide comprehensive guidance regarding diagnostics, counseling, and treatment recommendations.</p>

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Kommentierung der KDIGO-Leitlinie 2025 zur ADPKD

  • 期刊论文

  • 发表日期：

    2026年7月17日

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  • Malte P. Bartram,
  • Carsten Bergmann,
  • Roman-Ulrich Müller

摘要

Autosomal dominant polycystic kidney disease (ADPKD) is the most frequent genetic kidney disorder. In addition to the loss of kidney function caused by the continuous growth of cysts, numerous extrarenal manifestations are possible. These can include cysts in the liver or pancreas, cerebral aneurysms and valvular heart diseases. There is often uncertainty regarding which diagnostic tests are necessary for patients with suspected ADPKD and which follow-up measures and specific treatment recommendations should be followed once the diagnosis is confirmed. The Kidney Disease: Improving Global Outcomes (KDIGO) guidelines on ADPKD, published in 2025, provide comprehensive guidance regarding diagnostics, counseling, and treatment recommendations.