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<p>Chronic kidney disease (CKD) exhibits a&#xa0;higher global prevalence in women, particularly in early disease stages characterized by reduced estimated glomerular filtration rates (eGFR), whereas men more frequently develop severe disease courses with pronounced albuminuria, faster progression and kidney failure. Sex-related differences in the prevalence of CKD are multifactorial and arise from biological factors, such as hormonal effects, sex-dependent gene expression and immunological differences as well as from social and healthcare system-related influences. Etiologically, vascular and hypertensive causes predominate in both sexes but, in addition, women more commonly present with autoimmune-mediated kidney diseases. Despite comparable efficacy of modern nephroprotective treatment, women are less likely to receive guideline-concordant treatment. Sex-specific aspects should be taken more into consideration in research, clinical guidelines and clinical treatment of CKD.</p>

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Geschlechterunterschiede in der Prävalenz der chronischen Nierenkrankheit

  • 期刊论文

  • 发表日期：

    2026年3月2日

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  • Laura Katharina Sievers,
  • Sylvia Stracke

摘要

Chronic kidney disease (CKD) exhibits a higher global prevalence in women, particularly in early disease stages characterized by reduced estimated glomerular filtration rates (eGFR), whereas men more frequently develop severe disease courses with pronounced albuminuria, faster progression and kidney failure. Sex-related differences in the prevalence of CKD are multifactorial and arise from biological factors, such as hormonal effects, sex-dependent gene expression and immunological differences as well as from social and healthcare system-related influences. Etiologically, vascular and hypertensive causes predominate in both sexes but, in addition, women more commonly present with autoimmune-mediated kidney diseases. Despite comparable efficacy of modern nephroprotective treatment, women are less likely to receive guideline-concordant treatment. Sex-specific aspects should be taken more into consideration in research, clinical guidelines and clinical treatment of CKD.