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<p>Due to the increasing prevalence of chronic conditions, such as chronic kidney disease (CKD), the quality of life of patients is gaining importance as a&#xa0;key outcome in clinical research and healthcare. We consider so-called patient-reported outcomes (PROs) or self-reported health indicators, to be measurable and modifiable indicators of overall quality of life. These PROs encompass physical, psychological and social aspects of health and can be used to assess treatment success, for monitoring health status during care or for screening. Relevant PROs for patients with CKD and undergoing dialysis have been defined by initiatives, such as the standardized outcomes in nephrology (SONG) and the International Consortium for Health Outcome Measurement (ICHOM) and include fatigue, participation, physical functioning and depressive symptoms, among others. The PROs are assessed using standardized questionnaires known as patient-reported outcome measures (PROMs). A&#xa0;wide range of disease-specific and generic PROMs are available. In general, CKD and dialysis are associated with a reduced quality of life. The CONVINCE study investigated differences in mortality and quality of life among 1360 patients in 6 European countries treated with either hemodialysis (HD) or hemodiafiltration (HDF). During the CONVINCE study 118 patients (17.3%) in the HDF group and 148 patients (21.9%) in the HD group died, corresponding to a&#xa0;hazard ratio of 0.77 (95% confidence interval, 0.65–0.93). In addition, a&#xa0;slower decline in quality of life was observed among those receiving HDF, particularly with respect to physical and cognitive functioning.</p>

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Dialyse und Lebensqualität

  • 期刊论文

  • 发表日期：

    2025年7月24日

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  • Felix Fischer,
  • Anna Schappert,
  • Isabel Ottlewski,
  • Krister Cromm,
  • Matthias Rose

摘要

Due to the increasing prevalence of chronic conditions, such as chronic kidney disease (CKD), the quality of life of patients is gaining importance as a key outcome in clinical research and healthcare. We consider so-called patient-reported outcomes (PROs) or self-reported health indicators, to be measurable and modifiable indicators of overall quality of life. These PROs encompass physical, psychological and social aspects of health and can be used to assess treatment success, for monitoring health status during care or for screening. Relevant PROs for patients with CKD and undergoing dialysis have been defined by initiatives, such as the standardized outcomes in nephrology (SONG) and the International Consortium for Health Outcome Measurement (ICHOM) and include fatigue, participation, physical functioning and depressive symptoms, among others. The PROs are assessed using standardized questionnaires known as patient-reported outcome measures (PROMs). A wide range of disease-specific and generic PROMs are available. In general, CKD and dialysis are associated with a reduced quality of life. The CONVINCE study investigated differences in mortality and quality of life among 1360 patients in 6 European countries treated with either hemodialysis (HD) or hemodiafiltration (HDF). During the CONVINCE study 118 patients (17.3%) in the HDF group and 148 patients (21.9%) in the HD group died, corresponding to a hazard ratio of 0.77 (95% confidence interval, 0.65–0.93). In addition, a slower decline in quality of life was observed among those receiving HDF, particularly with respect to physical and cognitive functioning.