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Purpose <p>Soft tissue pathologies and bone defects are not easily visible in intra-operative fluoroscopic images; therefore, we develop an end-to-end MRI-to-fluoroscopic image registration framework, aiming to enhance intra-operative visualization for surgeons during orthopedic procedures.</p> Methods <p>The proposed framework utilizes deep learning to segment MRI scans and generate synthetic CT (sCT) volumes. These sCT volumes are then used to produce digitally reconstructed radiographs (DRRs), enabling 2D/3D registration with intra-operative fluoroscopic images. The framework’s performance was validated through simulation and cadaver studies for core decompression (CD) surgery, focusing on the registration accuracy of femur and pelvic regions.</p> Results <p>The framework achieved a mean translational registration accuracy of 2.4 ± 1.0 mm and rotational accuracy of 1.6 ± <InlineEquation ID="IEq1"> <InlineMediaObject> <ImageObject Color="BlackWhite" FileRef="11548_2025_3426_Article_IEq1.gif" Format="GIF" Height="14" Rendition="HTML" Resolution="72" Type="Linedraw" Width="30" /> </InlineMediaObject> <EquationSource Format="TEX">\(0.8^{\circ }\)</EquationSource> <EquationSource Format="MATHML"><math> <mrow> <mn>0</mn> <mo>.</mo> <msup> <mn>8</mn> <mo>∘</mo> </msup> </mrow> </math></EquationSource> </InlineEquation> for the femoral region in cadaver studies. The method successfully enabled intra-operative visualization of necrotic lesions that were not visible on conventional fluoroscopic images, marking a significant advancement in image guidance for femur and pelvic surgeries.</p> Conclusion <p>The MRI-to-fluoroscopic registration framework offers a novel approach to image guidance in orthopedic surgeries, exclusively using MRI without the need for CT scans. This approach enhances the visualization of soft tissues and bone defects, reduces radiation exposure, and provides a safer, more effective alternative for intra-operative surgical guidance.</p>

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End-to-end 2D/3D registration from pre-operative MRI to intra-operative fluoroscopy for orthopedic procedures

  • 期刊论文

  • 发表日期：

    2025年5月30日

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  • Ping-Cheng Ku,
  • Mingxu Liu,
  • Robert Grupp,
  • Andrew Harris,
  • Julius K. Oni,
  • Simon C. Mears,
  • Alejandro Martin-Gomez,
  • Mehran Armand

摘要

Purpose

Soft tissue pathologies and bone defects are not easily visible in intra-operative fluoroscopic images; therefore, we develop an end-to-end MRI-to-fluoroscopic image registration framework, aiming to enhance intra-operative visualization for surgeons during orthopedic procedures.

Methods

The proposed framework utilizes deep learning to segment MRI scans and generate synthetic CT (sCT) volumes. These sCT volumes are then used to produce digitally reconstructed radiographs (DRRs), enabling 2D/3D registration with intra-operative fluoroscopic images. The framework’s performance was validated through simulation and cadaver studies for core decompression (CD) surgery, focusing on the registration accuracy of femur and pelvic regions.

Results

The framework achieved a mean translational registration accuracy of 2.4 ± 1.0 mm and rotational accuracy of 1.6 ± \(0.8^{\circ }\) 0 . 8 ∘ for the femoral region in cadaver studies. The method successfully enabled intra-operative visualization of necrotic lesions that were not visible on conventional fluoroscopic images, marking a significant advancement in image guidance for femur and pelvic surgeries.

Conclusion

The MRI-to-fluoroscopic registration framework offers a novel approach to image guidance in orthopedic surgeries, exclusively using MRI without the need for CT scans. This approach enhances the visualization of soft tissues and bone defects, reduces radiation exposure, and provides a safer, more effective alternative for intra-operative surgical guidance.