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<p>Functional plasticity has been demonstrated in multiple sclerosis (MS) studies. However, the intrinsic brain activity complexity alterations remain unclear. Here, using a coarse-graining time-series procedure algorithm, we obtained multiscale entropy (MSE) from a retrospective multi-centre dataset (208 relapsing–remitting MS patients and 228 healthy controls). By linear mixed model analysis, we demonstrated (1) increased entropy at scale 1 and decreased entropy at scale 6, indicating that regional brain activity shifted towards randomness in the stable MS subgroups (<i>n</i> = 159), and (2) decreased entropy across scales 1–6, trending towards regularity in the acute MS subgroups (<i>n</i> = 49). The main results of the correlation analysis included the following: (1) Decreased entropy was associated with lesion volume and brain volume specifically on longer time scales (scale 3–5), and (2) increased entropy of scale 3 was associated with clinical disability scores. These findings reflect the critical role of structural disruption in the brain activity complexity of BOLD signals in MS patients.</p>

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Complexity of intrinsic brain activity in relapsing–remitting multiple sclerosis patients: patterns, association with structural damage, and clinical disability

  • 期刊论文

  • 发表日期：

    2025年1月7日

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  • Fuqing Zhou,
  • Zhizheng Zhuo,
  • Lin Wu,
  • Yuxin Li,
  • Ningnannan Zhang,
  • Xuemei Han,
  • Chun Zeng,
  • Lei Wang,
  • Xiaoya Chen,
  • Muhua Huang,
  • Yanyan Zhu,
  • Haiqing Li,
  • Guanmei Cao,
  • Jie Sun,
  • Yongmei Li,
  • Yunyun Duan

摘要

Functional plasticity has been demonstrated in multiple sclerosis (MS) studies. However, the intrinsic brain activity complexity alterations remain unclear. Here, using a coarse-graining time-series procedure algorithm, we obtained multiscale entropy (MSE) from a retrospective multi-centre dataset (208 relapsing–remitting MS patients and 228 healthy controls). By linear mixed model analysis, we demonstrated (1) increased entropy at scale 1 and decreased entropy at scale 6, indicating that regional brain activity shifted towards randomness in the stable MS subgroups (n = 159), and (2) decreased entropy across scales 1–6, trending towards regularity in the acute MS subgroups (n = 49). The main results of the correlation analysis included the following: (1) Decreased entropy was associated with lesion volume and brain volume specifically on longer time scales (scale 3–5), and (2) increased entropy of scale 3 was associated with clinical disability scores. These findings reflect the critical role of structural disruption in the brain activity complexity of BOLD signals in MS patients.