<p>Understanding the persistence of herbicides in soil is critical for achieving effective weed control while minimizing environmental risks. This study investigated the dissipation dynamics of metribuzin and flufenacet in potato under varying application strategies, planting systems, and irrigation schedules. Field experiments were conducted over two cropping seasons (2023–2024 and 2024–2025) using a single pre-emergence application of metribuzin at 350&#xa0;g a.i. ha⁻¹, a pre-mix formulation of flufenacet (24%) + metribuzin (17.5%) applied at 622.5&#xa0;g a.i. ha⁻¹ and split applications of metribuzin at 175&#xa0;g a.i. ha⁻¹ as pre-emergence followed by 175&#xa0;g a.i. ha⁻¹ as post-emergence in ridge and broad-bed planting systems combined with early and delayed irrigation. Results indicated that split applications of metribuzin exhibited the longest persistence, with half-lives ranging from 31.68 to 43.43&#xa0;days, maintaining biologically active concentrations over an extended period. Pre-mix applications showed moderately enhanced dissipation compared to single pre-emergence treatments. Ridge planting resulted in slower herbicide degradation with half-lives ranging from 11.01 to 43.43&#xa0;days as compared to broad-bed systems (9.62 to 40.69&#xa0;days). Irrigation timing significantly influenced persistence, with delayed irrigation (20&#xa0;days after planting) extending half-lives (13.33 to 43.43&#xa0;days) compared to early irrigation (2&#xa0;days after planting, 9.62 to 38.55&#xa0;days). The residues of studied herbicides in soil (&lt; 0.01&#xa0;µg&#xa0;g⁻¹) at harvest were below detectable levels, indicating minimal risk of carryover to succeeding crops. Residues in potato samples consistently remained within the permissible safety limits and the hazard quotient was less than 1, confirming that when applied at recommended doses, the herbicides dissipate effectively without leaving harmful residues, thereby ensuring the safety of the crop produce.</p>