<p>In clinical practice, the upper limb function of hemiplegic post-stroke patients is commonly evaluated using clinical tests and questionnaires. Performing a reliable investigation of compensatory strategies adopted for the upper limb movement may shed light on the basis of motor control and the mechanism of functional recovery. To quantitatively evaluate the compensatory strategies in post-stroke hemiplegic patients, we conducted an observational study in which 36 hemiplegic patients were enrolled and were stratified according to the Fugl-Meyer score. We assessed compensatory strategies in upper limb movements, specifically reaching (RCH) and hand-to-mouth (HTM) movements, using the Kinect V2 device. 11 severe, 8 severe-moderate, 9 moderate-mild, and 8 mild patients and 17 controls participated in the study. Our results showed that severe, severe-moderate, and moderate-mild patients can be discriminated from healthy participants in almost all parameters. In particular, patients showed a reduced ROM of the shoulder in RCH, higher shoulder and elbow vertical displacement, and lower wrist vertical displacement in HTM. Interestingly, compensatory parameters also discriminate mild patients from healthy controls, such as head frontal and vertical displacements. Our protocol works effectively and the instrumental assessment of compensatory strategies in post-stroke patients allows to discriminate different levels of impairments even with low-cost devices.</p> Graphical Abstract <p></p>