Abstract <p>Neurodegenerative disorders (NDD) represent a broad spectrum of diseases that progressively impact neurological function, yet available therapeutics remain conspicuously limited. They lead to altered rhythms and dynamics of walking, which are evident in the sequential footfall contact times measured from one stride to the next. Early detection of aberrant walking patterns can prevent the progression of risks associated with neurodegenerative diseases, enabling timely intervention and management. In this study, we propose a new methodology based on a parallel-path ConvMixer neural network for neurodegenerative disease classification from gait analysis. Earlier research in this field depended on either gait parameter-derived features or the ground reaction force signal. This study has emerged to combine both ground reaction force signals and extracted features to improve gait pattern analysis. The study is being carried out on the gait dynamics in the NDD database, i.e., on the benchmark dataset Physionet gaitndd. Leave one out cross-validation is carried out. The proposed model achieved the best average rates of accuracy, precision, recall, and an F1-score of 97.77<InlineEquation ID="IEq1"> <InlineMediaObject> <ImageObject Color="BlackWhite" FileRef="11517_2025_3334_Article_IEq1.gif" Format="GIF" Height="16" Rendition="HTML" Resolution="72" Type="Linedraw" Width="15" /> </InlineMediaObject> <EquationSource Format="TEX">\(\%\)</EquationSource> <EquationSource Format="MATHML"><math> <mo>%</mo> </math></EquationSource> </InlineEquation>, 96.37<InlineEquation ID="IEq2"> <InlineMediaObject> <ImageObject Color="BlackWhite" FileRef="11517_2025_3334_Article_IEq1.gif" Format="GIF" Height="16" Rendition="HTML" Resolution="72" Type="Linedraw" Width="15" /> </InlineMediaObject> <EquationSource Format="TEX">\(\%\)</EquationSource> <EquationSource Format="MATHML"><math> <mo>%</mo> </math></EquationSource> </InlineEquation>, 96.5<InlineEquation ID="IEq3"> <InlineMediaObject> <ImageObject Color="BlackWhite" FileRef="11517_2025_3334_Article_IEq1.gif" Format="GIF" Height="16" Rendition="HTML" Resolution="72" Type="Linedraw" Width="15" /> </InlineMediaObject> <EquationSource Format="TEX">\(\%\)</EquationSource> <EquationSource Format="MATHML"><math> <mo>%</mo> </math></EquationSource> </InlineEquation>, and 96.25<InlineEquation ID="IEq4"> <InlineMediaObject> <ImageObject Color="BlackWhite" FileRef="11517_2025_3334_Article_IEq1.gif" Format="GIF" Height="16" Rendition="HTML" Resolution="72" Type="Linedraw" Width="15" /> </InlineMediaObject> <EquationSource Format="TEX">\(\%\)</EquationSource> <EquationSource Format="MATHML"><math> <mo>%</mo> </math></EquationSource> </InlineEquation>, respectively. The experimental findings demonstrate that our approach outperforms the best results achieved by other state-of-the-art methods.</p> Graphical abstract <p></p>

错误:搜索内容不能为空,请输入英文关键词
错误:关键词超出字数限制,请精简
高级检索

A new parallel-path ConvMixer neural network for predicting neurodegenerative diseases from gait analysis

  • Jihen Fourati,
  • Mohamed Othmani,
  • Khawla Ben Salah,
  • Hela Ltifi

摘要

Abstract

Neurodegenerative disorders (NDD) represent a broad spectrum of diseases that progressively impact neurological function, yet available therapeutics remain conspicuously limited. They lead to altered rhythms and dynamics of walking, which are evident in the sequential footfall contact times measured from one stride to the next. Early detection of aberrant walking patterns can prevent the progression of risks associated with neurodegenerative diseases, enabling timely intervention and management. In this study, we propose a new methodology based on a parallel-path ConvMixer neural network for neurodegenerative disease classification from gait analysis. Earlier research in this field depended on either gait parameter-derived features or the ground reaction force signal. This study has emerged to combine both ground reaction force signals and extracted features to improve gait pattern analysis. The study is being carried out on the gait dynamics in the NDD database, i.e., on the benchmark dataset Physionet gaitndd. Leave one out cross-validation is carried out. The proposed model achieved the best average rates of accuracy, precision, recall, and an F1-score of 97.77 \(\%\) % , 96.37 \(\%\) % , 96.5 \(\%\) % , and 96.25 \(\%\) % , respectively. The experimental findings demonstrate that our approach outperforms the best results achieved by other state-of-the-art methods.

Graphical abstract