Scholarlink

<p>In this study, the preparation of hydrogel beads through electrostatic interactions between Ι-carrageenan (IC) and ε-polylysine (ε-PL) using a dropwise method is reported. As the concentration of ε-PL increased, the degree of swelling of the hydrogel beads decreased. FTIR and XRD analyses revealed shifts in the absorption peaks, suggesting the formation of hydrogen bonding, electrostatic interactions in the hydrogel beads. TGA showed that the mass loss of the IC/ε-PL hydrogel beads was significantly lower compared to that of pure ε-PL. These results indicate that the IC component has a protective stabilizing effect on the hydrogel structure. ε-PL concentration of 2% yielded the highest encapsulation efficiency of curcumin (Cur) in the hydrogel beads. In vitro release studies showed that the hydrogel beads sustained the release of Cur and the release kinetics followed the first-order and Hixson-Crowell models. Collectively, these findings demonstrate that these hydrogel beads have the potential to be effective carriers of hydrophobic substances.</p> Graphical Abstract <p></p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Fabrications of Ι-Carrageenan/ε-Polylysine Hydrogel Beads for Curcumin Encapsulation and Controlled Release Behavior in Vitro

  • 期刊论文

  • 发表日期：

    2025年2月1日

查看全文
  • Jiaxiang Zang,
  • Liling Song,
  • Chang Ge,
  • LanLan Zhang,
  • Bakht Ramin Shah,
  • Xianling Wei,
  • Wei Xu

摘要

In this study, the preparation of hydrogel beads through electrostatic interactions between Ι-carrageenan (IC) and ε-polylysine (ε-PL) using a dropwise method is reported. As the concentration of ε-PL increased, the degree of swelling of the hydrogel beads decreased. FTIR and XRD analyses revealed shifts in the absorption peaks, suggesting the formation of hydrogen bonding, electrostatic interactions in the hydrogel beads. TGA showed that the mass loss of the IC/ε-PL hydrogel beads was significantly lower compared to that of pure ε-PL. These results indicate that the IC component has a protective stabilizing effect on the hydrogel structure. ε-PL concentration of 2% yielded the highest encapsulation efficiency of curcumin (Cur) in the hydrogel beads. In vitro release studies showed that the hydrogel beads sustained the release of Cur and the release kinetics followed the first-order and Hixson-Crowell models. Collectively, these findings demonstrate that these hydrogel beads have the potential to be effective carriers of hydrophobic substances.

Graphical Abstract